ArticleDevelopment (Cambridge, England)2018
Revealing age-related changes of adult hippocampal neurogenesis using mathematical models.
Article in Development (Cambridge, England), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
29 citing papers in PubMed.
- Harnessing biological variability for mechanistic inference: A stochastic framework applied to neural stem cell dynamics.iScience · 2026Article
- The hippocampal subgranular zone neurogenic niche: a modular perspective on neural stem cell regulation.Frontiers in cellular neuroscience · 2026Review
- Beyond Bayesian Inference: The Correlation Integral Likelihood Framework and Gradient Flow Methods for Deterministic Sampling.Bulletin of mathematical biology · 2025Article
- Vitamin D Associated with Exercise Can Be Used as a Promising Tool in Neurodegenerative Disease Protection.Molecules (Basel, Switzerland) · 2025Review
- Unraveling regulatory feedback mechanisms in adult neurogenesis through mathematical modelling.NPJ systems biology and applications · 2025Article
- Multimodal transcriptomics reveal neurogenic aging trajectories and age-related regional inflammation in the dentate gyrus.Nature neuroscience · 2025Article
- Beyond the canonical niche: how astrocytes carried neurogenic potential into the brain parenchyma.Frontiers in cell and developmental biology · 2025Review
- Rescue of neurogenesis and age-associated cognitive decline in SAMP8 mouse: Role of transforming growth factor-alpha.Aging cell · 2023Article
- Neuron stem cell NLRP6 sustains hippocampal neurogenesis to resist stress-induced depression.Acta pharmaceutica Sinica. B · 2023Article
- Chronic in vivo imaging defines age-dependent alterations of neurogenesis in the mouse hippocampus.Nature aging · 2023Article
- Mathematical modeling and application of IL-1β/TNF signaling pathway in regulating chondrocyte apoptosis.Frontiers in cell and developmental biology · 2023Article
- Roles of Chromatin Remodelling and Molecular Heterogeneity in Therapy Resistance in Glioblastoma.Cancers · 2022Review
- Identifying stem cell numbers and functional heterogeneities during postembryonic organ growth.iScience · 2022Article
- Dynamic spatiotemporal coordination of neural stem cell fate decisions occurs through local feedback in the adult vertebrate brain.Cell stem cell · 2021Article
- Early stem cell aging in the mature brain.Cell stem cell · 2021Article
- Coordinated changes in cellular behavior ensure the lifelong maintenance of the hippocampal stem cell population.Cell stem cell · 2021Article
- Long-term self-renewing stem cells in the adult mouse hippocampus identified by intravital imaging.Nature neuroscience · 2021Article
- Vascular Senescence: A Potential Bridge Between Physiological Aging and Neurogenic Decline.Frontiers in neuroscience · 2021Review
- Mechanisms of enhanced quiescence in neural stem cell aging.Mechanisms of ageing and development · 2020Review
- Age-related loss of neural stem cell O-GlcNAc promotes a glial fate switch through STAT3 activation.Proceedings of the National Academy of Sciences of the United States of America · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
New neurons are continuously generated in the dentate gyrus of the adult hippocampus. This continuous supply of newborn neurons is important to modulate cognitive functions. Yet the number of newborn neurons declines with age. Increasing Wnt activity upon loss of dickkopf 1 can counteract both the decline of newborn neurons and the age-related cognitive decline. However, the precise cellular changes underlying the age-related decline or its rescue are fundamentally not understood. The present study combines a mathematical model and experimental data to address features controlling neural stem cell (NSC) dynamics. We show that available experimental data fit a model in which quiescent NSCs may either become activated to divide or may undergo depletion events, such as astrocytic transformation and apoptosis. Additionally, we demonstrate that old NSCs remain quiescent longer and have a higher probability of becoming re-activated than depleted. Finally, our model explains that high NSC-Wnt activity leads to longer time in quiescence while enhancing the probability of activation. Altogether, our study shows that modulation of the quiescent state is crucial to regulate the pool of stem cells throughout the life of an animal.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.