Evidence map›Paper›PMID 29229723›Full record

ArticleStroke2018

Prospective Study of Fasting Blood Glucose and Intracerebral Hemorrhagic Risk.

Cheng Jin, Guohong Li, Kathryn M Rexrode, Mahmut E Gurol, Xiaodong Yuan, Ying Hui, Chunyu Ruan, Anand Vaidya, Yanxiu Wang, Shouling Wu and 1 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Stroke, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
33citing papers in PubMed, 2 pooled it
3.5field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

33 citing papers in PubMed, 2 syntheses or guidelines pooled it, 59 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
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  4. Plasma urate concentrations and possible REM sleep behavior disorder.Annals of clinical and translational neurology · 2019
    Trial
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  20. A practical approach to the management of cerebral amyloid angiopathy.International journal of stroke : official journal of the International Stroke Society · 2021
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 2 countries.

Cheng JinFrom the Department of Cardiology (C.J., C.R., Y.W., S.W.), Department of Neurology (X.Y.), and Department of Medical Imaging (Y.H.), Kailuan General Hospital, Tangshan, China; Department of Nutritional Sciences, State College, Pennsylvania State University, University Park (C.J., X.G.); School of Public Health, Shanghai Jiao Tong University School of Medicine, China (G.L.); Division of Preventive Medicine (K.R.) and Division of Endocrinology, Diabetes, and Hypertension (A.V.), Brigham and Women's Hospital, Boston, MA; and Hemorrhagic Stroke Research Program, Massachusetts General Hospital, Harvard Medical School, Boston (M.E.G.).
Guohong LiFrom the Department of Cardiology (C.J., C.R., Y.W., S.W.), Department of Neurology (X.Y.), and Department of Medical Imaging (Y.H.), Kailuan General Hospital, Tangshan, China; Department of Nutritional Sciences, State College, Pennsylvania State University, University Park (C.J., X.G.); School of Public Health, Shanghai Jiao Tong University School of Medicine, China (G.L.); Division of Preventive Medicine (K.R.) and Division of Endocrinology, Diabetes, and Hypertension (A.V.), Brigham and Women's Hospital, Boston, MA; and Hemorrhagic Stroke Research Program, Massachusetts General Hospital, Harvard Medical School, Boston (M.E.G.).
Kathryn M RexrodeFrom the Department of Cardiology (C.J., C.R., Y.W., S.W.), Department of Neurology (X.Y.), and Department of Medical Imaging (Y.H.), Kailuan General Hospital, Tangshan, China; Department of Nutritional Sciences, State College, Pennsylvania State University, University Park (C.J., X.G.); School of Public Health, Shanghai Jiao Tong University School of Medicine, China (G.L.); Division of Preventive Medicine (K.R.) and Division of Endocrinology, Diabetes, and Hypertension (A.V.), Brigham and Women's Hospital, Boston, MA; and Hemorrhagic Stroke Research Program, Massachusetts General Hospital, Harvard Medical School, Boston (M.E.G.).
Mahmut E GurolFrom the Department of Cardiology (C.J., C.R., Y.W., S.W.), Department of Neurology (X.Y.), and Department of Medical Imaging (Y.H.), Kailuan General Hospital, Tangshan, China; Department of Nutritional Sciences, State College, Pennsylvania State University, University Park (C.J., X.G.); School of Public Health, Shanghai Jiao Tong University School of Medicine, China (G.L.); Division of Preventive Medicine (K.R.) and Division of Endocrinology, Diabetes, and Hypertension (A.V.), Brigham and Women's Hospital, Boston, MA; and Hemorrhagic Stroke Research Program, Massachusetts General Hospital, Harvard Medical School, Boston (M.E.G.).
Xiaodong YuanFrom the Department of Cardiology (C.J., C.R., Y.W., S.W.), Department of Neurology (X.Y.), and Department of Medical Imaging (Y.H.), Kailuan General Hospital, Tangshan, China; Department of Nutritional Sciences, State College, Pennsylvania State University, University Park (C.J., X.G.); School of Public Health, Shanghai Jiao Tong University School of Medicine, China (G.L.); Division of Preventive Medicine (K.R.) and Division of Endocrinology, Diabetes, and Hypertension (A.V.), Brigham and Women's Hospital, Boston, MA; and Hemorrhagic Stroke Research Program, Massachusetts General Hospital, Harvard Medical School, Boston (M.E.G.).
Ying HuiFrom the Department of Cardiology (C.J., C.R., Y.W., S.W.), Department of Neurology (X.Y.), and Department of Medical Imaging (Y.H.), Kailuan General Hospital, Tangshan, China; Department of Nutritional Sciences, State College, Pennsylvania State University, University Park (C.J., X.G.); School of Public Health, Shanghai Jiao Tong University School of Medicine, China (G.L.); Division of Preventive Medicine (K.R.) and Division of Endocrinology, Diabetes, and Hypertension (A.V.), Brigham and Women's Hospital, Boston, MA; and Hemorrhagic Stroke Research Program, Massachusetts General Hospital, Harvard Medical School, Boston (M.E.G.).
Chunyu RuanFrom the Department of Cardiology (C.J., C.R., Y.W., S.W.), Department of Neurology (X.Y.), and Department of Medical Imaging (Y.H.), Kailuan General Hospital, Tangshan, China; Department of Nutritional Sciences, State College, Pennsylvania State University, University Park (C.J., X.G.); School of Public Health, Shanghai Jiao Tong University School of Medicine, China (G.L.); Division of Preventive Medicine (K.R.) and Division of Endocrinology, Diabetes, and Hypertension (A.V.), Brigham and Women's Hospital, Boston, MA; and Hemorrhagic Stroke Research Program, Massachusetts General Hospital, Harvard Medical School, Boston (M.E.G.).
Anand VaidyaFrom the Department of Cardiology (C.J., C.R., Y.W., S.W.), Department of Neurology (X.Y.), and Department of Medical Imaging (Y.H.), Kailuan General Hospital, Tangshan, China; Department of Nutritional Sciences, State College, Pennsylvania State University, University Park (C.J., X.G.); School of Public Health, Shanghai Jiao Tong University School of Medicine, China (G.L.); Division of Preventive Medicine (K.R.) and Division of Endocrinology, Diabetes, and Hypertension (A.V.), Brigham and Women's Hospital, Boston, MA; and Hemorrhagic Stroke Research Program, Massachusetts General Hospital, Harvard Medical School, Boston (M.E.G.).
Yanxiu WangFrom the Department of Cardiology (C.J., C.R., Y.W., S.W.), Department of Neurology (X.Y.), and Department of Medical Imaging (Y.H.), Kailuan General Hospital, Tangshan, China; Department of Nutritional Sciences, State College, Pennsylvania State University, University Park (C.J., X.G.); School of Public Health, Shanghai Jiao Tong University School of Medicine, China (G.L.); Division of Preventive Medicine (K.R.) and Division of Endocrinology, Diabetes, and Hypertension (A.V.), Brigham and Women's Hospital, Boston, MA; and Hemorrhagic Stroke Research Program, Massachusetts General Hospital, Harvard Medical School, Boston (M.E.G.).
Shouling WuFrom the Department of Cardiology (C.J., C.R., Y.W., S.W.), Department of Neurology (X.Y.), and Department of Medical Imaging (Y.H.), Kailuan General Hospital, Tangshan, China; Department of Nutritional Sciences, State College, Pennsylvania State University, University Park (C.J., X.G.); School of Public Health, Shanghai Jiao Tong University School of Medicine, China (G.L.); Division of Preventive Medicine (K.R.) and Division of Endocrinology, Diabetes, and Hypertension (A.V.), Brigham and Women's Hospital, Boston, MA; and Hemorrhagic Stroke Research Program, Massachusetts General Hospital, Harvard Medical School, Boston (M.E.G.). xxg14@psu.edu drwusl@163.com.
Xiang GaoFrom the Department of Cardiology (C.J., C.R., Y.W., S.W.), Department of Neurology (X.Y.), and Department of Medical Imaging (Y.H.), Kailuan General Hospital, Tangshan, China; Department of Nutritional Sciences, State College, Pennsylvania State University, University Park (C.J., X.G.); School of Public Health, Shanghai Jiao Tong University School of Medicine, China (G.L.); Division of Preventive Medicine (K.R.) and Division of Endocrinology, Diabetes, and Hypertension (A.V.), Brigham and Women's Hospital, Boston, MA; and Hemorrhagic Stroke Research Program, Massachusetts General Hospital, Harvard Medical School, Boston (M.E.G.). xxg14@psu.edu drwusl@163.com.
Pennsylvania State University · USBrigham and Women's Hospital · USShanghai Jiao Tong University · CN

Funding

Interactions Between Adrenal and Parathyroid Hormones in Human HealthR01DK107407 · NIDDK · BRIGHAM AND WOMEN'S HOSPITAL · PI VAIDYA, ANAND · 2015 to 2019
$2.5M
Vitamin D and Hormonal Mechanisms of Cardiovascular Disease in ObesityK23HL111771 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI VAIDYA, ANAND · 2012 to 2016
$805k
Statins, statin-related gene, and Parkinson's disease riskR21NS087235 · NINDS · PENNSYLVANIA STATE UNIVERSITY, THE · PI GAO, XIANG · 2014 to 2015
$398k
NHLBI NIH HHS K23 HL111771NIDDK NIH HHS R01 DK107407NINDS NIH HHS R21 NS087235
6 · The paper itself

Abstract

background and purposeAlthough diabetes mellitus is an established independent risk factor for ischemic stroke, the association between fasting blood glucose and intracerebral hemorrhage (ICH) is limited and inconsistent. The objective of the current study was to examine the potential impact of long-term fasting blood glucose concentration on subsequent risk of ICH.

methodsThis prospective study included 96 110 participants of the Kailuan study, living in Kailuan community, Tangshan city, China, who were free of cardiovascular diseases and cancer at baseline (2006). Fasting blood glucose concentration was measured in 2006, 2008, 2010, and 2012. Updated cumulative average fasting blood glucose concentration was used as primary exposure of the current study. Incident ICH from 2006 to 2015 was confirmed by review of medical records.

resultsDuring 817 531 person-years of follow-up, we identified 755 incident ICH cases. The nadir risk of ICH was observed at fasting blood glucose concentration of 5.3 mmol/L. The adjusted hazard ratios and their 95% confidence intervals (CIs) of ICH were 1.59 (95% CI, 1.26-2.02) for diabetes mellitus or fasting blood glucose ≥7.00 mmol/L, 1.31 (95% CI, 1.02-1.69) for impaired fasting blood glucose (fasting blood glucose, 6.10-6.99 mmol/L), 0.98 (95% CI, 0.78-1.22) for fasting blood glucose 5.60 to 6.09 mmol/L, and 2.04 (95% CI, 1.23-3.38) for hypoglycemia (fasting blood glucose, <4.00 mmol/L), comparing with normal fasting blood glucose 4.00 to 5.59 mmol/L. The results persisted after excluding individuals who used hypoglycemic, aspirin, antihypertensive agents, or anticoagulants, and those with intracerebral hemorrhagic cases occurred in the first 2 years of follow-up.

conclusionsIn this large community-based cohort, low (<4.0 mmol/L) and high (≥6.1 mmol/L) fasting blood glucose concentrations were associated with higher risk of incident ICH, relative to fasting blood glucose concentrations of 4.00 to 6.09 mmol/L.

Indexed as

Cerebral HemorrhageAdolescentAdultAgedAged, 80 and overBlood GlucoseChinaFastingFemaleFollow-Up StudiesHumansIncidenceMaleMiddle AgedProspective StudiesRisk FactorsBlood Glucosecerebral hemorrhagediabetes mellitusfollow-up studieshumansrisk factors

Identifiers

PMID29229723
PMCPMC5914501
OpenAlexW2772863574

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.