Evidence map›Paper›PMID 29229639›Full record

ArticleAntimicrobial agents and chemotherapy2018

Whole-Cell Screen of Fragment Library Identifies Gut Microbiota Metabolite Indole Propionic Acid as Antitubercular.

Dereje A Negatu, Joe J J Liu, Matthew Zimmerman, Firat Kaya, Véronique Dartois, Courtney C Aldrich, Martin Gengenbacher, Thomas Dick

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Antimicrobial agents and chemotherapy, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.

0numbers the graph read from it
0cells of the map it votes in
36citing papers in PubMed
4.0field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

36 citing papers in PubMed, 70 citations in OpenAlex.

  1. Article
  2. Review
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  4. Frontiers in cellular and infection microbiology · 2026
    Article
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  6. Review
  7. Article
  8. Review
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  10. Article
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  18. Antibiotic Resistance toAntibiotics (Basel, Switzerland) · 2022
    Review
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  20. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 2 countries.

Dereje A NegatuAntibacterial Drug Discovery Laboratory, Department of Microbiology and Immunology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore.
Joe J J LiuTuberculosis Research Laboratory, Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore.
Matthew ZimmermanPublic Health Research Institute, New Jersey Medical School, Rutgers, The State University of New Jersey, Newark, New Jersey, USA.
Firat KayaPublic Health Research Institute, New Jersey Medical School, Rutgers, The State University of New Jersey, Newark, New Jersey, USA.
Véronique DartoisPublic Health Research Institute, New Jersey Medical School, Rutgers, The State University of New Jersey, Newark, New Jersey, USA.
Courtney C AldrichDepartment of Medicinal Chemistry, College of Pharmacy, University of Minnesota, Minneapolis, Minnesota, USA.
Martin GengenbacherTuberculosis Research Laboratory, Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore mg1435@njms.rutgers.edu td367@njms.rutgers.edu.ORCID 0000-0002-0208-5920
Thomas DickAntibacterial Drug Discovery Laboratory, Department of Microbiology and Immunology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore mg1435@njms.rutgers.edu td367@njms.rutgers.edu.ORCID 0000-0002-9604-9452
Rutgers, The State University of New Jersey · USNational University of Singapore · SGUniversity of Minnesota · US

Funding

A QTRAP 6500 LC-MS/MS System from SCIEX for high accuracy drug content analysisS10OD023524 · OD · RBHS-NEW JERSEY MEDICAL SCHOOL · PI DARTOIS, VERONIQUE · 2017 to 2017
$526k
NIH HHS S10 OD023524
6 · The paper itself

Abstract

Several key antituberculosis drugs, including pyrazinamide, with a molecular mass of 123.1 g/mol, are smaller than the usual drug-like molecules. Current drug discovery efforts focus on the screening of larger compounds with molecular masses centered around 400 to 500 g/mol. Fragment (molecular mass < 300 g/mol) libraries have not been systematically explored for antitubercular activity. Here we screened a collection of 1,000 fragments, present in the Maybridge Ro3 library, for whole-cell activity against

Indexed as

AnimalsAntitubercular AgentsFemaleGastrointestinal MicrobiomeMiceMice, Inbred BALB CMicrobial Sensitivity TestsMycobacterium tuberculosisPropionatesPyrazinamideAntitubercular AgentsPropionatespropionic acidPyrazinamidefragmentsgut microbiotaindole propionic acidtuberculosis

Identifiers

PMID29229639
PMCPMC5826148
OpenAlexW2773986159

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.