Evidence map›Paper›PMID 29229636›Full record

ArticleAntimicrobial agents and chemotherapy2018

Topical Antibiotic Use Coselects for the Carriage of Mobile Genetic Elements Conferring Resistance to Unrelated Antimicrobials in Staphylococcus aureus.

Glen P Carter, Mark B Schultz, Sarah L Baines, Anders Gonçalves da Silva, Helen Heffernan, Audrey Tiong, Peter H Pham, Ian R Monk, Timothy P Stinear, Benjamin P Howden and 1 more

Abstract read
In one paragraph

Article in Antimicrobial agents and chemotherapy, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Genomic and functional divergence ofMicrobiology spectrum · 2024
    Article
  5. Adding Fuel to the Fire? The Skin Microbiome in Atopic Dermatitis.The Journal of investigative dermatology · 2024
    Review
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Review
  13. Article
  14. Article
  15. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Glen P Carter *Department of Microbiology & Immunology, Doherty Institute, The University of Melbourne, Melbourne, Australia glen.carter@unimelb.edu.au deborah.williamson@unimelb.edu.au.
Mark B Schultz *Department of Microbiology & Immunology, Doherty Institute, The University of Melbourne, Melbourne, Australia.ORCID 0000-0002-7689-6531
Sarah L BainesDepartment of Microbiology & Immunology, Doherty Institute, The University of Melbourne, Melbourne, Australia.
Anders Gonçalves da SilvaDepartment of Microbiology & Immunology, Doherty Institute, The University of Melbourne, Melbourne, Australia.
Helen HeffernanInstitute of Environmental Science and Research, Wellington, New Zealand.
Audrey TiongInstitute of Environmental Science and Research, Wellington, New Zealand.
Peter H PhamDoherty Applied Microbial Genomics, Doherty Institute, The University of Melbourne, Melbourne, Australia.
Ian R MonkDepartment of Microbiology & Immunology, Doherty Institute, The University of Melbourne, Melbourne, Australia.
Timothy P StinearDepartment of Microbiology & Immunology, Doherty Institute, The University of Melbourne, Melbourne, Australia.
Benjamin P HowdenDepartment of Microbiology & Immunology, Doherty Institute, The University of Melbourne, Melbourne, Australia.
Deborah A WilliamsonDepartment of Microbiology & Immunology, Doherty Institute, The University of Melbourne, Melbourne, Australia glen.carter@unimelb.edu.au deborah.williamson@unimelb.edu.au.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Topical antibiotics, such as mupirocin and fusidic acid, are commonly used in the prevention and treatment of skin infections, particularly those caused by staphylococci. However, the widespread use of these agents is associated with increased resistance to these agents, potentially limiting their efficacy. Of particular concern is the observation that resistance to topical antibiotics is often associated with multidrug resistance, suggesting that topical antibiotics may play a role in the emergence of multidrug-resistant (MDR) strains. New Zealand (NZ) has some of the highest globally recorded rates of topical antibiotic usage and resistance. Using a combination of Pacific Biosciences single-molecule real-time (SMRT) whole-genome sequencing, Illumina short-read sequencing, and Bayesian phylogenomic modeling on 118 new multilocus sequence type 1 (ST1) community

Indexed as

Administration, TopicalAnti-Bacterial AgentsBayes TheoremDrug Resistance, Multiple, BacterialFusidic AcidGenome, BacterialHumansMicrobial Sensitivity TestsMupirocinNew ZealandStaphylococcal InfectionsStaphylococcal Skin InfectionsStaphylococcus aureusAnti-Bacterial AgentsFusidic AcidMupirocincoselectionfusidic acidmultidrug resistancemupirocinplasmidsStaphylococcus aureustopical antibiotics

Identifiers

PMID29229636
PMCPMC5786761

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.