Evidence map›Paper›PMID 29229606›Full record

ArticleCancer research2018

Coactivation of Estrogen Receptor and IKKβ Induces a Dormant Metastatic Phenotype in ER-Positive Breast Cancer.

Lamiaa El-Shennawy, Oleksii Dubrovskyi, Irida Kastrati, Jeanne M Danes, Yiqun Zhang, Herbert E Whiteley, Chad J Creighton, Jonna Frasor

Open access · bronzeAbstract read
In one paragraph

Article in Cancer research, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.

0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed
1.4field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

26 citing papers in PubMed, 38 citations in OpenAlex.

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  15. Tumor Dormancy: Implications for Invasion and Metastasis.International journal of molecular sciences · 2021
    Review
  16. Review
  17. Autophagy and Cancer Dormancy.Frontiers in oncology · 2021
    Review
  18. Article
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 2 countries.

Lamiaa El-ShennawyDepartment of Physiology and Biophysics, University of Illinois at Chicago, Chicago, Illinois.
Oleksii DubrovskyiDepartment of Physiology and Biophysics, University of Illinois at Chicago, Chicago, Illinois.
Irida KastratiDepartment of Physiology and Biophysics, University of Illinois at Chicago, Chicago, Illinois.
Jeanne M DanesDepartment of Physiology and Biophysics, University of Illinois at Chicago, Chicago, Illinois.
Yiqun ZhangDan L. Duncan Comprehensive Cancer Center, Baylor College of Medicine, Houston, Texas.
Herbert E WhiteleyCollege of Veterinary Medicine, University of Illinois, Urbana, Illinois.
Chad J CreightonDan L. Duncan Comprehensive Cancer Center, Baylor College of Medicine, Houston, Texas.
Jonna FrasorDepartment of Physiology and Biophysics, University of Illinois at Chicago, Chicago, Illinois. jfrasor@uic.edu.
Alexandria University · EGBaylor College of Medicine · US

Funding

Tumor BiologyP30CA125123 · NCI · BAYLOR COLLEGE OF MEDICINE · PI DAVID R ROWLEY · 2007 to 2026
$73.9M
Estrogen Receptor and NFkB Crosstalk in Breast CancerR01CA200669 · NCI · UNIVERSITY OF ILLINOIS AT CHICAGO · PI Jonathan L. Coloff · 2016 to 2026
$4.8M
NCI NIH HHS P30 CA125123NCI NIH HHS R01 CA200669
6 · The paper itself

Abstract

A growing body of evidence suggests that the inflammatory NFκB pathway is associated with the progression of ER

Indexed as

AnimalsBreast NeoplasmsCell Line, TumorCell ProliferationFemaleHumansI-kappa B KinaseMiceMice, NudePhenotypeReceptors, EstrogenSignal TransductionI-kappa B KinaseReceptors, Estrogen

Identifiers

PMID29229606
PMCPMC5815896
OpenAlexW2773266395

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.