ArticleRadiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology2018
Patient reported dry mouth: Instrument comparison and model performance for correlation with quality of life in head and neck cancer survivors.
Article in Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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14 citing papers in PubMed, 25 citations in OpenAlex.
- Network analysis of head and neck symptoms and fear of cancer recurrence in postoperative laryngeal cancer patients: simulation-based intervention modeling.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2026Article
- Individual patient-reported symptom items discriminate imaging-graded dysphagia in head and neck cancer patients treated with radiotherapy: secondary analysis of pooled prospective studies.Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology · 2026Article
- Patient-reported outcomes after ipsilateral radiation therapy for N2b tonsillar squamous cell carcinoma.Discover oncology · 2025Article
- Evaluation of a comprehensive set of normal tissue complication probability models for patients with head and neck cancer in an international cohort.Oral oncology · 2025Article
- Identifying dose constraints for the parotid ducts to minimize patient-reported xerostomia: Is conventional mean dose sparing of the parotid glands sufficient?Journal of applied clinical medical physics · 2024Article
- Effects of Neck Radiation Therapy on Carotid Arteries in Patients with Head and Neck Carcinoma.Galen medical journal · 2024Article
- Mastication, swallowing, and salivary flow in patients with head and neck cancer: objective tests versus patient-reported outcomes.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2021Article
- Determinants of patient-reported xerostomia among long-term oropharyngeal cancer survivors.Cancer · 2021Article
- A prospective study of patient-reported xerostomia-related outcomes after parotidectomy.Laryngoscope investigative otolaryngology · 2021Article
- Intensity-modulated proton therapy for oropharyngeal cancer reduces rates of late xerostomia.Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology · 2021Article
- Xerostomia-related quality of life for patients with oropharyngeal carcinoma treated with proton therapy.Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology · 2020Article
- Priorities of human papillomavirus-associated oropharyngeal cancer patients at diagnosis and after treatment.Oral oncology · 2019Article
- Article
- Physical symptoms in long-term survivors of rare cancer.Journal of cancer survivorship : research and practice · 2018Article
Corrections and comments
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Authors and funding
26 authors at 4 institutions in 4 countries.
Funding
Abstract
purposeTo identify a clinically meaningful cut-point for the single item dry mouth question of the MD Anderson Symptom Inventory-Head and Neck module (MDASI-HN).
methodsHead and neck cancer survivors who had received radiation therapy (RT) completed the MDASI-HN, the University of Michigan Hospital Xerostomia Questionnaire (XQ), and the health visual analog scale (VAS) of the EuroQol Five Dimension Questionnaire (EQ-5D). The Bayesian information criteria (BIC) were used to test the prediction power of each tool for EQ-5D VAS. The modified Breiman recursive partitioning analysis (RPA) was used to identify a cut point of the MDASI-HN dry mouth score (MDASI-HN-DM) with EQ-5D VAS, using a ROC-based approach; regression analysis was used to confirm the threshold effect size.
resultsTwo-hundred seven respondents formed the cohort. Median follow-up from the end of RT to questionnaire completion was 88 months. The single item MDASI-HN-DM score showed a linear relationship with the XQ composite score (ρ = 0.80, p < 0.001). The MDASI-HN-DM displayed improved model performance for association with EQ-5D VAS as compared to XQ (BIC of 1803.7 vs. 2016.9, respectively). RPA showed that an MDASI-HN-DM score of ≥6 correlated with EQ-5D VAS decline (LogWorth 5.5).
conclusionThe single item MDASI-HN-DM correlated with the multi-item XQ and performed favorably in the prediction of QOL. A MDASI-HN-DM cut point of ≥6 correlated with decline in QOL.
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