ArticleThe Journal of hospital infection2018
Pseudomonas aeruginosa intensive care unit outbreak: winnowing of transmissions with molecular and genomic typing.
Article in The Journal of hospital infection, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed.
- Long-Term Environmental Surveillance ofPathogens (Basel, Switzerland) · 2026Article
- Article
- Carbapenem-ResistantAntibiotics (Basel, Switzerland) · 2025Review
- Isolation of Acanthamoeba Species and Bacterial Symbiont Variability in Puna Salt Plains, Argentina.Environmental microbiology reports · 2025Article
- Rapid Drug Susceptibility Testing to Preserve Antibiotics.Methods in molecular biology (Clifton, N.J.) · 2024Review
- Application of Pathogen Genomics to Outbreak Investigation.Methods in molecular biology (Clifton, N.J.) · 2024Article
- The RNA from Pseudomonas aeruginosa Reduces Neutrophil Responses Favoring Bacterial Survival.Journal of innate immunity · 2024Article
- Introduction and benchmarking of pyMLST: open-source software for assessing bacterial clonality using core genome MLST.Microbial genomics · 2023Article
- Genomic characteristics and comparative genomics analysis of Salmonella enterica subsp. enterica serovar Thompson isolated from an outbreak in South Korea.Scientific reports · 2022Article
- New Variants of PseudomonasMicroorganisms · 2022Article
- Genomic-based transmission analysis of carbapenem-resistantJAC-antimicrobial resistance · 2022Article
- Whole Genome Multi-Locus Sequence Typing and Genomic Single Nucleotide Polymorphism Analysis for Epidemiological Typing ofFrontiers in microbiology · 2022Article
- Field Grand Challenge Frontiers in Antibiotics.Frontiers in antibiotics · 2022Article
- Diversity in the composition of the accessory genome of Mexican Pseudomonas aeruginosa strains.Genes & genomics · 2022Article
- β-lactam Resistance inPathogens (Basel, Switzerland) · 2021Review
- High-Voltage, Pulsed Electric Fields EliminateAdvances in wound care · 2021Article
- Clinical perspectives in integrating whole-genome sequencing into the investigation of healthcare and public health outbreaks - hype or help?The Journal of hospital infection · 2021Article
- Establishment and Evaluation of a Core Genome Multilocus Sequence Typing Scheme for Whole-Genome Sequence-Based Typing of Pseudomonas aeruginosa.Journal of clinical microbiology · 2021Article
- It's Not Easy Being Green: A Narrative Review on the Microbiology, Virulence and Therapeutic Prospects of Multidrug-ResistantAntibiotics (Basel, Switzerland) · 2021Review
- Genotypic characterisation and antimicrobial resistance of Pseudomonas aeruginosa strains isolated from patients of different hospitals and medical centres in Poland.BMC infectious diseases · 2020Article
Corrections and comments
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundPseudomonas aeruginosa healthcare outbreaks can be time consuming and difficult to investigate. Guidance does not specify which typing technique is most practical for decision-making.
aimTo explore the usefulness of whole-genome sequencing (WGS) in the investigation of a P. aeruginosa outbreak, describing how it compares with pulsed-field gel electrophoresis (PFGE) and variable number tandem repeat (VNTR) analysis.
methodsSix patient isolates and six environmental samples from an intensive care unit (ICU) positive for P. aeruginosa over two years underwent VNTR, PFGE and WGS.
findingsVNTR and PFGE were required to fully determine the potential source of infection and rule out others. WGS results unambiguously distinguished linked isolates, giving greater assurance of the transmission route between wash-hand basin water and two patients, supporting the control measures employed.
conclusionWGS provided detailed information without the need for further typing. When allied to epidemiological information, WGS can be used to understand outbreak situations rapidly and with certainty. Implementation of WGS in real-time would be a major advance in day-to-day practice. It could become a standard of care as it becomes more widespread due to its reproducibility and lower costs.
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