Evidence map›Paper›PMID 29229445›Full record

ReviewProgress in retinal and eye research2018

Optical coherence tomography angiography.

Richard F Spaide, James G Fujimoto, Nadia K Waheed, Srinivas R Sadda, Giovanni Staurenghi

3 registry-linked trialsOpen access · hybridAbstract readReview
In one paragraph

Review in Progress in retinal and eye research, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 3 registered trials, which are not on this map. Cited by 944 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
944citing papers in PubMed, 5 pooled it
88.5field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04593212 unknown statusnot on this mapstarted 2023, after this paper: background citation

Improving the Assessment of Microcirculatory Dysfunction in Septic Shock Patients Using Optical Coherence Tomography Angiography at the Bedside

TypeobservationalSponsorHospital da Luz, PortugalRan2023 to 2024Enrolled165ConditionsSeptic ShockArmsOptical Coherence Tomography Angiography
NCT05747144 unknown statusnot on this mapstarted 2021, after this paper: background citation

Multimodal Imaging in Vitreo-retinal Surgery and Macular Dystrophies: Biomarkers of Morpho-Functional Recovery by Artificial Intelligence

TypeobservationalSponsorFondazione Policlinico Universitario Agostino Gemelli IRCCSRan2021 to 2025Enrolled100ConditionsMacular Holes, Epiretinal Membrane, Retinal Detachment, Macular DystrophiesArmsBiometry, Retinography (Color) + Autofluorescence (AF), OCT B-scan and OCT angiography (OCTA), Microperimetry, Electrophysiological exams
NCT06296004 unknown statusnot on this mapstarted 2024, after this paper: background citation

Relation Between Nail Fold Capillaroscopy, Optical Coherence Tomography Angiography, and Femoral Vein Wall Thickness in Behçet's Disease

Typeobservational_patient_registrySponsorAssiut UniversityRan2024 to 2025Enrolled80ConditionsBehçet's DiseaseArmsNail Fold Capillaroscopy, Optical Coherence Tomography Angiography, and Femoral Vein Wall Thickness by U.S
3 · Its place in the literature

Who cites it

944 citing papers in PubMed, 5 syntheses or guidelines pooled it, 1,650 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Pooled it
  5. Pooled it
  6. Trial
  7. Integrated multimodal assessment of retinal oxygenation, hemodynamics, and neurovisual function in retinal vein occlusion.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2026
    Article
  8. Review
  9. Optical coherence tomography angiography of the macular retina and choroid in glaucoma: a narrative review.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2026
    Review
  10. Observational
  11. Article
  12. Article
  13. Article
  14. Widefield optical coherence tomography angiography of fellow eyes in patients with Coats Disease.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2026
    Article
  15. Article
  16. Observational
  17. Article
  18. Article
  19. Article
  20. Article

884 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 5 institutions in 2 countries.

Richard F SpaideVitreous, Retina, Macula Consultants of New York, New York, NY, United States. Electronic address: rickspaide@gmail.com.
James G FujimotoDepartment of Electrical Engineering & Computer Science and Research Laboratory of Electronics, Massachusetts Institute of Technology, Cambridge MA, United States.
Nadia K WaheedThe Department of Ophthalmology, Tufts University School of Medicine, Boston MA, United States.
Srinivas R SaddaDoheny Eye Institute, University of California - Los Angeles, Los Angeles, CA, United States.
Giovanni StaurenghiEye Clinic, Department of Biomedical and Clinical Sciences "Luigi Sacco", Luigi Sacco Hospital, University of Milan, Milan, Italy.
Massachusetts Institute of Technology · USTufts University · USUniversity of California, Los Angeles · USUniversity of Milan · ITVitreous Retina Macula Consultants of New York · US

Funding

Novel Glaucoma Diagnostics for Structure and Function - Renewal - 1R01EY013178 · NEI · WILLS EYE HEALTH SYSTEM · PI Joel S Schuman · 2000 to 2026
$17.5M
Novel Optical Diagnostics with Optical Coherence TomographyR01EY011289 · NEI · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI JAMES G FUJIMOTO · 1995 to 2026
$9.5M
NEI NIH HHS R01 EY011289NEI NIH HHS R01 EY013178
6 · The paper itself

Abstract

Optical coherence tomography (OCT) was one of the biggest advances in ophthalmic imaging. Building on that platform, OCT angiography (OCTA) provides depth resolved images of blood flow in the retina and choroid with levels of detail far exceeding that obtained with older forms of imaging. This new modality is challenging because of the need for new equipment and processing techniques, current limitations of imaging capability, and rapid advancements in both imaging and in our understanding of the imaging and applicable pathophysiology of the retina and choroid. These factors lead to a steep learning curve, even for those with a working understanding dye-based ocular angiography. All for a method of imaging that is a little more than 10 years old. This review begins with a historical account of the development of OCTA, and the methods used in OCTA, including signal processing, image generation, and display techniques. This forms the basis to understand what OCTA images show as well as how image artifacts arise. The anatomy and imaging of specific vascular layers of the eye are reviewed. The integration of OCTA in multimodal imaging in the evaluation of retinal vascular occlusive diseases, diabetic retinopathy, uveitis, inherited diseases, age-related macular degeneration, and disorders of the optic nerve is presented. OCTA is an exciting, disruptive technology. Its use is rapidly expanding in clinical practice as well as for research into the pathophysiology of diseases of the posterior pole.

Indexed as

Diagnostic Techniques, OphthalmologicalChoroidFluorescein AngiographyHumansImage Processing, Computer-AssistedRetinal DiseasesTomography, Optical CoherenceMultimodal imagingOptical coherence tomographyOptical coherence tomography angiography

Identifiers

PMID29229445
PMCPMC6404988
OpenAlexW2775636951

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.