ReviewProgress in retinal and eye research2018
Neural control of choroidal blood flow.
Review in Progress in retinal and eye research, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 134 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
134 citing papers in PubMed, 2 syntheses or guidelines pooled it, 243 citations in OpenAlex.
- Exploring the role of oxidative stress in retinal vein occlusion: an updated and comprehensive review on the pathophysiology and treatment perspectives.International ophthalmology · 2025Pooled it
- Retinal VIP-amacrine cells: their development, structure, and function.Eye (London, England) · 2024Pooled it
- Effects of Chinese Acupoint Eye Exercise on Ocular Biological Parameters.Translational vision science & technology · 2025Trial
- Short-Term Effect of Stimulating the Pterygopalatine Ganglion Via Electroacupuncture on Choroidal Structure in Human Subjects.Translational vision science & technology · 2024Trial
- Choriocapillaris Perfusion after 8 Weeks of High-Speed Circuit Training in Older Healthy Adults.Current eye research · 2024Trial
- Estimating pulsatile ocular blood volume from intraocular pressure, ocular pulse amplitude, and axial length.PloS one · 2023Trial
- A moderate dosage of coffee causes acute retinal capillary perfusion decrease in healthy young individuals.BMC ophthalmology · 2022Trial
- Single-cell transcriptomic atlas of the human fetal uveal tract reveals heterogeneity in melanocyte populations.iScience · 2026Article
- Quantitative Changes in Iris Vessel Area Density During Valsalva Maneuver in Healthy Eyes.Translational vision science & technology · 2026Article
- Ocular manifestations of lichen planus: a comparative analysis of tear function, choroidal thickness, and retinal parameters.BMC ophthalmology · 2026Article
- Layer-specific choroidal vascular adaptation to high-altitude hypoxia revealed by functional OCT at 3,800 m.Function (Oxford, England) · 2026Article
- Functional and Structural Outcomes of Photodynamic Therapy (PDT) With or Without Eplerenone for Central Serous Chorioretinopathy.Journal of clinical medicine · 2026Article
- Macular choriocapillaris perfusion area: a potential biomarker of mild cognitive impairment in patients with cerebral small vessel disease.Stroke and vascular neurology · 2026Observational
- Choroidal Changes in Cerebral Amyloid Angiopathy Studied by Optical Coherence Tomography Angiography.Translational stroke research · 2026Article
- In-depth analysis of retinal RNA transcriptome sequencing in a rat model of hypertensive retinopathy.Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences · 2026Article
- Retinal and choroidal changes in young adults during near work and eye closure measured by wide-field OCTA.BMC ophthalmology · 2026Article
- Association Between PCSK9 Inhibitor Use and Risk of Age-Related Macular Degeneration.Translational vision science & technology · 2026Article
- Investigation of Skin Circulation Hemodynamics Using Skin Laser Speckle Flowgraphy After Trapezius Muscle Self-Stretching.Muscles (Basel, Switzerland) · 2026Article
- Effect of Tonsillar Retractor on Intracranial and Intraocular Pressure in Children Undergoing Adenotonsillectomy Surgeries.Laryngoscope investigative otolaryngology · 2026Article
- Saccades orchestrate intraocular glucose dynamics to shape visual responses in birds.Nature communications · 2026Article
74 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
The choroid is richly innervated by parasympathetic, sympathetic and trigeminal sensory nerve fibers that regulate choroidal blood flow in birds and mammals, and presumably other vertebrate classes as well. The parasympathetic innervation has been shown to vasodilate and increase choroidal blood flow, the sympathetic input has been shown to vasoconstrict and decrease choroidal blood flow, and the sensory input has been shown to both convey pain and thermal information centrally and act locally to vasodilate and increase choroidal blood flow. As the choroid lies behind the retina and cannot respond readily to retinal metabolic signals, its innervation is important for adjustments in flow required by either retinal activity, by fluctuations in the systemic blood pressure driving choroidal perfusion, and possibly by retinal temperature. The former two appear to be mediated by the sympathetic and parasympathetic nervous systems, via central circuits responsive to retinal activity and systemic blood pressure, but adjustments for ocular perfusion pressure also appear to be influenced by local autoregulatory myogenic mechanisms. Adaptive choroidal responses to temperature may be mediated by trigeminal sensory fibers. Impairments in the neural control of choroidal blood flow occur with aging, and various ocular or systemic diseases such as glaucoma, age-related macular degeneration (AMD), hypertension, and diabetes, and may contribute to retinal pathology and dysfunction in these conditions, or in the case of AMD be a precondition. The present manuscript reviews findings in birds and mammals that contribute to the above-summarized understanding of the roles of the autonomic and sensory innervation of the choroid in controlling choroidal blood flow, and in the importance of such regulation for maintaining retinal health.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.