ArticleJournal of Ayurveda and integrative medicine
Pharmacodynamic evaluation of self micro-emulsifying formulation of standardized extract of Lagerstroemia speciosa for antidiabetic activity.
Article in Journal of Ayurveda and integrative medicine. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed, 23 citations in OpenAlex.
- A review of the pharmacological mechanism of corosolic acid.Frontiers in pharmacology · 2026Review
- Self-Emulsifying Drug Delivery System Enhances the Antidiabetic Activity ofPharmaceutics · 2025Article
- Floral Elegance Meets Medicinal Marvels: Traditional Uses, Phytochemistry, and Pharmacology of the GenusPlants (Basel, Switzerland) · 2024Review
- Self-Emulsifying Systems for Delivery of Bioactive Compounds from Natural Origin.AAPS PharmSciTech · 2022Review
- Isolation of Thymol fromBioMed research international · 2022Article
- Design and characterization of propolis extract loaded self-nano emulsifying drug delivery system as immunostimulant.Saudi pharmaceutical journal : SPJ : the official publication of the Saudi Pharmaceutical Society · 2021Article
- Identification, ADMET evaluation and molecular docking analysis of Phytosterols from Banaba (In silico pharmacology · 2021Article
- Development of New Indonesian Propolis Extract-Loaded Self-emulsifying: Characterization, Stability and Antibacterial Activity.Advanced pharmaceutical bulletin · 2021Article
- Self microemulsifying formulation ofJournal of traditional and complementary medicine · 2018Article
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Authors and funding
3 authors at 3 institutions in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
backgroundLagerstroemia speciosa (SEL) leaves are a popular folk medicine for diabetes treatment due to presence of corosolic acid. It has low water solubility resulting poor absorption after oral administration. Self micro-emulsified drug delivery system is the way by which we can improve the oral absorption of drug.
objectiveThe objective of this study was to develop the self micro-emulsifying formulation of standardized extract of SEL leaves and evaluate its pharmacodynamic performance for antidiabetic activity. MATERIALS AND
methodsThe SME formulation was prepared by using sefsol-218 as oil, cremophor-EL as surfactant and transcutol-P as co-surfactant. The ratio of surfactant and co-surfactant was determined by pseudoternary phase diagram. SME formulations were characterized for dilution at different pH, self emulsification, optical clarity, globule size and thermodynamic stability. Pharmacodynamic evaluation of formulations was assessed in Wistar rats by using parameters viz. blood glucose level and serum lipid profile.
resultsSEL loaded SME formulation was successfully developed by using sefsol-218, cremophor-EL and transcutol-P with a droplet size 23.53 nm. Pharmacodynamic results showed a higher reduction in blood glucose by SME formulation than SEL without SMES respectively at 50 mg/kg dose while reduction produced at dose of 100 mg/kg was found significant and better on 15th day of study. The percentage reduction produced by SME formulation on serum lipid profile was also significant and was more prominent than SEL.
conclusionThis study confirms that the formulation elevates the pharmacodynamic performance of SEL approximately two fold.
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