ArticleThe Journal of infection2018
Potential of real-time PCR threshold cycle (C
Article in The Journal of infection, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
30 citing papers in PubMed, 2 syntheses or guidelines pooled it, 50 citations in OpenAlex.
- Systematic Review on the Correlation of Quantitative PCR Cycle Threshold Values of Gastrointestinal Pathogens With Patient Clinical Presentation and Outcomes.Frontiers in medicine · 2021Pooled it
- Diagnostic stewardship and the 2017 update of the IDSA-SHEA Clinical Practice Guidelines for Clostridium difficile Infection.Diagnosis (Berlin, Germany) · 2018Guideline
- PCR Cycle Threshold-Guided Management of PediatricMicroorganisms · 2026Article
- Full Factorial Comparison of the Diagnostic Performance of Three Nucleic Acid Extraction Kits and Three PRRSV RT-qPCR Assays Using Swine Oral Fluids of Known Status.Microorganisms · 2026Article
- Cycle thresholds and discordant 2-step testing for Clostridioides Difficile: Comparison of clinical characteristics and outcomes among discordant and true positive results.Antimicrobial stewardship & healthcare epidemiology : ASHE · 2026Article
- Use of PCR cycle threshold values for toxins A and B quantification in Clostridioides difficile infections.Scientific reports · 2025Article
- Management and Outcomes of Clostridioides difficile Infection in Patients on Immune Checkpoint Inhibitors.Journal of the National Comprehensive Cancer Network : JNCCN · 2025Article
- Comparative evaluation of the STANDARD M10 and XpertJournal of clinical microbiology · 2024Article
- Use of PCR Cycle Threshold and Clinical Interventions to Aid in the Management of PediatricMicroorganisms · 2024Article
- Novel Biomarkers, IncludingInfection and immunity · 2023Article
- Validation of Clinical Risk Models for Clostridioides difficileAntimicrobial agents and chemotherapy · 2022Article
- Article
- Binary Toxin Expression byOpen forum infectious diseases · 2022Article
- C. difficile and the Patient with Inflammatory Bowel Disease: A Testing Dilemma.Digestive diseases and sciences · 2021Article
- Propensity-Matched Cost ofOpen forum infectious diseases · 2021Article
- Evaluation of Cycle Threshold, Toxin Concentration, and Clinical Characteristics of Clostridioides difficile Infection in Patients with Discordant Diagnostic Test Results.Journal of clinical microbiology · 2020Article
- Patient Outcomes With Prevented vs NegativeOpen forum infectious diseases · 2020Article
- Laboratory Tests for the Diagnosis ofClinics in colon and rectal surgery · 2020Review
- The Role of Diagnostic Stewardship inCurrent infectious disease reports · 2020Article
- Dual Reporting of Clostridioides difficile PCR and Predicted Toxin Result Based on PCR Cycle Threshold Reduces Treatment of Toxin-Negative Patients without Increases in Adverse Outcomes.Journal of clinical microbiology · 2019Observational
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
Abstract
objectivesClostridium difficile infection (CDI) is a toxin-mediated disease. Oncology patients are at increased risk for developing CDI. Diagnosis of CDI by PCR has led to misclassification of some C. difficile carriers as CDI cases. We determined if an optimized C. difficile PCR cycle threshold value (C
methods183 consecutive patients positive for C. difficile by the Xpert C. difficile were additionally tested using the cell culture cytotoxicity neutralization assay (CYT) and enzyme immunoassays (EIA). C
resultsUsing CYT as the reference, ROC-derived Youden cut-off C
conclusionsLower C
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.