Evidence map›Paper›PMID 29229188›Full record

ReviewCurrent opinion in microbiology2017

Plasmodium P47: a key gene for malaria transmission by mosquito vectors.

Alvaro Molina-Cruz, Gaspar E Canepa, Carolina Barillas-Mury

Abstract readReview
In one paragraph

Review in Current opinion in microbiology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers.

0numbers the graph read from it
0cells of the map it votes in
41citing papers in PubMed
5.0field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

41 citing papers in PubMed, 57 citations in OpenAlex.

  1. Article
  2. Article
  3. Transcriptomics of Plasmodium vivax rosettingMemorias do Instituto Oswaldo Cruz · 2026
    Article
  4. Article
  5. Article
  6. Review
  7. Review
  8. Article
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  15. Article
  16. Role ofProceedings of the National Academy of Sciences of the United States of America · 2023
    Article
  17. Article
  18. Infectivity of symptomaticCurrent research in parasitology & vector-borne diseases · 2023
    Article
  19. Review
  20. Malaria parasite evades mosquito immunity by glutaminyl cyclase-mediated posttranslational protein modification.Proceedings of the National Academy of Sciences of the United States of America · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 1 country.

Alvaro Molina-CruzLaboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, MD 20852, United States. Electronic address: amolina-cruz@niaid.nih.gov.
Gaspar E CanepaLaboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, MD 20852, United States.
Carolina Barillas-MuryLaboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, MD 20852, United States. Electronic address: cbarillas@niaid.nih.gov.
National Institutes of Health · USNational Institute of Allergy and Infectious Diseases · US

Funding

Mosquito Immune Responses and Malaria TransmissionZIAAI000947 · NIAID · NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES · PI BARILLAS-MURY, CAROLINA · 2009 to 2025
$26.2M
Mosquito Midgut Immune Responses &Malaria TransmissionZ01AI000947 · NIAID · NIAID EXTRAMURAL ACTIVITIES · PI BARILLAS-MURY, CAROLINA · 2004 to 2008
$1.8M
Intramural NIH HHS Z01 AI000947Intramural NIH HHS Z99 AI999999
6 · The paper itself

Abstract

Malaria is caused by infection with Plasmodium parasites that have a complex life cycle. The parasite protein P47 is critical for disease transmission. P47 mediates mosquito immune evasion in both Plasmodium berghei (Pbs47) and Plasmodium falciparum (Pfs47), and has been shown to be important for optimal female gamete fertility in P. berghei. Pfs47 presents strong geographic structure in natural P. falciparum populations, consistent with natural selection of Pfs47 haplotypes by the mosquito immune system as the parasite adapted to new vector species worldwide. These key functions make Plasmodium P47 an attractive target to disrupt malaria transmission.

Indexed as

AnimalsFemaleHumansMalaria, FalciparumMosquito VectorsPlasmodium falciparumProtozoan ProteinsReproductionProtozoan Proteins

Identifiers

PMID29229188
PMCPMC5739336
OpenAlexW2771177862

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.