ArticleMicrobiome2017
The rumen microbiome as a reservoir of antimicrobial resistance and pathogenicity genes is directly affected by diet in beef cattle.
Article in Microbiome, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 124 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
124 citing papers in PubMed, 1 synthesis or guideline pooled it, 218 citations in OpenAlex.
- Variation in animal performance explained by the rumen microbiome or by diet composition.Journal of animal science · 2018Pooled it
- Age- and diet-driven assembly of the gut antibiotic resistome in humans and food-producing animals.Gut microbes · 2026Review
- Optimisation of selection for methane mitigation by integrating production traits with ruminal microbiome-driven breeding in beef cattle.Genetics, selection, evolution : GSE · 2026Article
- Bidirectional regulation of gut microbiota and young ruminant host: implications for intestinal development and mucosal immunity.Journal of animal science and biotechnology · 2026Review
- Effects of dietary allicin supplementation on nutrient digestion and gastrointestinal health of Guizhou black goats.Animal nutrition (Zhongguo xu mu shou yi xue hui) · 2026Article
- Predicting beef diet nutritional composition and intake from rumen metagenomic profiles.Animal nutrition (Zhongguo xu mu shou yi xue hui) · 2026Article
- Alterations in Blood Markers, Rumen Fermentation, and Microbiota Due to Heat Stress in Holstein Cows During the Dry Period and Early Lactation.Animals : an open access journal from MDPI · 2026Article
- Effects of Replacing Whole-Crop Maize Silage withAnimals : an open access journal from MDPI · 2026Article
- Effects of feeding agroindustrial byproducts on rumen fermentation and microbiome of sheep.JDS communications · 2026Article
- Integrating Diagnostic Tools for Early Recognition of Rumenitis in a Neonatal Calf.Animals : an open access journal from MDPI · 2026Article
- Host-microbiome interplay supports heat stress resilience in zebu calves.Animal microbiome · 2026Article
- Metagenomic analysis of antimicrobial resistance, virulence, and mobile genetic elements in the gut microbiota of Caprinae species.Communications biology · 2026Article
- Gut Microbiome Health in Farm Animals and Fish: Implications for Human Health and the Risk of Gastrointestinal Diseases.Microorganisms · 2026Review
- Co-Occurrence Patterns of Bacterial Communities and Resistance Genes: A Comprehensive Multi-Pen Fecal Microbiome and Resistome Study in Dairy Farms.Microorganisms · 2025Article
- Metagenomic Analysis Revealed Significant Changes in the Beef Cattle Rectum Microbiome Under Fescue Toxicosis.Biology · 2025Article
- Study on the Plateau Adaptive Synergistic Mechanism of Rumen Microbiome-Metabolome-Resistome in Tibetan Sheep.Microorganisms · 2025Article
- Comparative Analysis of Compound Probiotics, Seasonal Variation, and Age on Gut Microbial Composition and Function in Endangered Forest Musk Deer.Microorganisms · 2025Article
- Indole Propionic Acid Regulates Gut Immunity: Mechanisms of Metabolite-Driven Immunomodulation and Barrier Integrity.Journal of microbiology and biotechnology · 2025Review
- Microbial exchange at the wildlife-livestock interface: insights into microbial composition, antimicrobial resistance and virulence factor gene dynamics in grassland ecosystems.Animal microbiome · 2025Article
- Article
64 more citing papers are in PubMed but not listed here.
Corrections and comments
- Erratum issued
Authors and funding
9 authors at 5 institutions in 1 country.
Funding
Abstract
backgroundThe emergence and spread of antimicrobial resistance is the most urgent current threat to human and animal health. An improved understanding of the abundance of antimicrobial resistance genes and genes associated with microbial colonisation and pathogenicity in the animal gut will have a major role in reducing the contribution of animal production to this problem. Here, the influence of diet on the ruminal resistome and abundance of pathogenicity genes was assessed in ruminal digesta samples taken from 50 antibiotic-free beef cattle, comprising four cattle breeds receiving two diets containing different proportions of concentrate.
resultsTwo hundred and four genes associated with antimicrobial resistance (AMR), colonisation, communication or pathogenicity functions were identified from 4966 metagenomic genes using KEGG identification. Both the diversity and abundance of these genes were higher in concentrate-fed animals. Chloramphenicol and microcin resistance genes were dominant in samples from forage-fed animals (P < 0.001), while aminoglycoside and streptomycin resistances were enriched in concentrate-fed animals. The concentrate-based diet also increased the relative abundance of Proteobacteria, which includes many animal and zoonotic pathogens. A high ratio of Proteobacteria to (Firmicutes + Bacteroidetes) was confirmed as a good indicator for rumen dysbiosis, with eight cases all from concentrate-fed animals. Finally, network analysis demonstrated that the resistance/pathogenicity genes are potentially useful as biomarkers for health risk assessment of the ruminal microbiome.
conclusionsDiet has important effects on the complement of AMR genes in the rumen microbial community, with potential implications for human and animal health.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.