Evidence map›Paper›PMID 29228815›Full record

ArticleJournal of evidence-based complementary & alternative medicine2017

Acute and Subchronic Toxicity Studies of Aqueous Extract of Desmodium adscendens (Sw) DC.

Osbourne Quaye, Precious Cramer, Mark Ofosuhene, Laud K N Okine, Alexander K Nyarko

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of evidence-based complementary & alternative medicine, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
1.5field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 8 citations in OpenAlex.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Osbourne Quaye1 Department of Biochemistry, Cell & Molecular Biology, University of Ghana, Legon, Accra, Ghana.ORCID 0000-0002-0621-876X
Precious Cramer1 Department of Biochemistry, Cell & Molecular Biology, University of Ghana, Legon, Accra, Ghana.
Mark Ofosuhene3 Noguchi Memorial Institute for Medical Research, University of Ghana, Legon, Accra, Ghana.
Laud K N Okine1 Department of Biochemistry, Cell & Molecular Biology, University of Ghana, Legon, Accra, Ghana.
Alexander K Nyarko4 School of Pharmacy, University of Ghana, Legon, Accra, Ghana.
University of Ghana · GH

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Extracts of Desmodium adscendens (Sw) DC are used for the treatment of various diseases but limited toxicological evaluations have been done on the medicinal plant. This study investigates toxicity effects of the leave extract of D adscendens, and the possibility of drug-drug interaction of the plant extract when co-administered with other drugs. Oral administrations of leaf extract of D adscendens to white Wistar rats in an acute toxicity studies allowed the estimation of an LD

Indexed as

FabaceaePlant ExtractsAnimalsAnticonvulsantsDose-Response Relationship, DrugEthnopharmacologyGhanaHerb-Drug InteractionsHumansLethal Dose 50MaleMuscle Relaxants, CentralPlants, MedicinalRatsRats, WistarThiopentalAnticonvulsantsMuscle Relaxants, CentralPlant ExtractsThiopentalZoxazolamineacute toxicitycytochrome P450 xenobiotic-metabolizing enzymesDesmodium adscendens (Sw) DCdrug metabolismsubchronic toxicity

Identifiers

PMID29228815
PMCPMC5871315
OpenAlexW2767703132

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.