Evidence map›Paper›PMID 29228606›Full record

ArticleOncotarget2017

Identifying tumor promoting genomic alterations in tumor-associated fibroblasts via retrovirus-insertional mutagenesis.

Lijie Rong, Yangyang Bian, Shubai Liu, Xiaoman Liu, Xiao Li, Haiyang Liu, Jinxue Zhou, Jirun Peng, Henghui Zhang, Hongsong Chen and 1 more

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Oncotarget, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.1field-weighted citation impact, top 48% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 5 citations in OpenAlex.

  1. Review
  2. Article
  3. TTL-Expression Modulates Epithelial Morphogenesis.Frontiers in cell and developmental biology · 2021
    Article
  4. Article
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 6 institutions in 1 country.

Lijie RongMedical Research Center, The First Affiliated Hospital of Zhengzhou University, Zhengzhou University, Zhengzhou, 450052, China.
Yangyang BianMedical Research Center, The First Affiliated Hospital of Zhengzhou University, Zhengzhou University, Zhengzhou, 450052, China.
Shubai LiuKey Laboratory of Protein and Peptide Pharmaceuticals, Chinese Academy of Sciences-University of Tokyo, Beijing, 100101, China.
Xiaoman LiuKey Laboratory of Protein and Peptide Pharmaceuticals, Chinese Academy of Sciences-University of Tokyo, Beijing, 100101, China.
Xiao LiKey Laboratory of Protein and Peptide Pharmaceuticals, Chinese Academy of Sciences-University of Tokyo, Beijing, 100101, China.
Haiyang LiuKey Laboratory of Protein and Peptide Pharmaceuticals, Chinese Academy of Sciences-University of Tokyo, Beijing, 100101, China.
Jinxue ZhouHenan Tumor Hospital, Zhengzhou, 450008, China.
Jirun PengDepartment of Surgery, Beijing Shijitan Hospital, Capital Medical University, Beijing, 100038, China.
Henghui ZhangPeking University People's Hospital, Peking University Hepatology Institute, Beijing, 100044, China.
Hongsong ChenPeking University People's Hospital, Peking University Hepatology Institute, Beijing, 100044, China.
Zhihai QinMedical Research Center, The First Affiliated Hospital of Zhengzhou University, Zhengzhou University, Zhengzhou, 450052, China.
Institute of Biophysics · CNBeijing Shijitan Hospital · CNChinese Academy of Sciences · CNFirst Affiliated Hospital of Zhengzhou University · CNPeking University · CNPeking University People's Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Tumor-associated fibroblasts (TAFs) are often essential for solid tumor growth. However, few genetic or epigenetic alterations have been found in TAFs during the progression of solid tumors. Employing a tumor-stromal cell co-injection model, we adapted here retroviral-insertional mutagenesis to stromal cells to identify novel tumor-associated genes in TAFs. We successfully identified 20 gene candidates that might modulate tumor growth if altered in TAFs at genomic level. To validate our finding, the function of one of the candidate genes, tubulin tyrosine ligase (

Indexed as

co-injection modelretrovirus-insertional mutagenesisTtlTumor-associated fibroblaststumor-promoting gene

Identifiers

PMID29228606
PMCPMC5722558
OpenAlexW2765494736

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.