ArticleInvestigative ophthalmology & visual science2017
Higher Contrast Requirement for Letter Recognition and Macular RGC+ Layer Thinning in Glaucoma Patients and Older Adults.
Article in Investigative ophthalmology & visual science, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 21 citations in OpenAlex.
- Significant Age-Related Visual Declines but Preserved Binocular Summation of Contrast Sensitivity and Visual Acuity Across Adulthood.Investigative ophthalmology & visual science · 2025Article
- Age-Related Changes in Mesopic Reading Vision Across Adulthood.Investigative ophthalmology & visual science · 2025Article
- Impact of Glaucomatous Ganglion Cell Damage on Central Visual Function.Annual review of vision science · 2024Review
- Correlation of contrast sensitivity with ganglion cell/inner plexiform layer thickness and damage location in glaucoma with varying severity.Eye (London, England) · 2024Article
- MNREAD Reading Vision in Adults With Glaucoma Under Mesopic and Photopic Conditions.Investigative ophthalmology & visual science · 2023Article
- Evaluation of the Glaucomatous Macular Damage by Chromatic Pupillometry.Ophthalmology and therapy · 2023Article
- Despite Impaired Binocular Function, Binocular Disparity Integration Across the Visual Field Is Spared in Normal Aging and Glaucoma.Investigative ophthalmology & visual science · 2023Article
- Foveal crowding appears to be robust to normal aging and glaucoma unlike parafoveal and peripheral crowding.Journal of vision · 2022Article
- Identifying the Retinal Layers Linked to Human Contrast Sensitivity Via Deep Learning.Investigative ophthalmology & visual science · 2022Article
- Binocularly Asymmetric Crowding in Glaucoma and a Lack of Binocular Summation in Crowding.Investigative ophthalmology & visual science · 2022Article
- A Unified Rule for Binocular Contrast Summation Applies to Normal Vision and Common Eye Diseases.Investigative ophthalmology & visual science · 2021Article
- Relationship Between Flicker Modulation Sensitivity and Retinal Ganglion Cell Related Layer Thicknesses.Translational vision science & technology · 2021Article
- High-Pass Visual Acuity Loss and Macular Structure-Function Relationship in Patients With Primary Open-Angle Glaucoma.Translational vision science & technology · 2021Article
- Low-Contrast High-Pass Visual Acuity Might Help to Detect Glaucoma Damage: A Structure-Function Analysis.Frontiers in medicine · 2021Article
- Increased Equivalent Input Noise in Glaucomatous Central Vision: Is it Due to Undersampling of Retinal Ganglion Cells?Investigative ophthalmology & visual science · 2020Article
- Relationship Between Acuity and Contrast Sensitivity: Differences Due to Eye Disease.Investigative ophthalmology & visual science · 2020Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Purpose: Growing evidence suggests the involvement of the macula even in early stages of glaucoma. However, little is known about the impact of glaucomatous macular damage on central pattern vision. Here we examine the contrast requirement for letter recognition and its relationship with retinal thickness in the macular region. Methods: A total of 40 participants were recruited: 13 patients with glaucoma (mean age = 65.6 ± 6.6 years), 14 age-similar normally sighted adults (59.1 ± 9.1 years), and 13 young normally sighted adults (21.0 ± 2.0 years). For each participant, letter-recognition contrast thresholds were obtained using a letter recognition task in which participants identified English letters presented at varying retinal locations across the central 12° visual field, including the fovea. The macular retinal ganglion cell plus inner plexiform (RGC+) layer thickness was also evaluated using spectral-domain optical coherence tomography (SD-OCT). Results: Compared to age-similar normal controls, glaucoma patients exhibited a significant increase in letter-recognition contrast thresholds (by 236%, P < 0.001) and a significant decrease in RGC+ layer thickness (by 17%, P < 0.001) even after controlling for age, pupil diameter, and visual acuity. Compared to normal young adults, older adults showed a significant increase in letter-recognition contrast thresholds and a significant decrease in RGC+ layer thickness. Across all subjects, the thickness of macular RGC+ layer was significantly correlated with letter-recognition contrast thresholds, even after correcting for pupil diameter and visual acuity (r = -0.65, P < 0.001). Conclusions: Our results show that both glaucoma and normal aging likely bring about a thinning of the macular RGC+ layer; the macular RGC+ layer thickness appears to be associated with the contrast requirements for letter recognition in central vision.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.