ArticleThe international journal of neuropsychopharmacology2018
Decreased Resting-State Interhemispheric Functional Connectivity Correlated with Neurocognitive Deficits in Drug-Naive First-Episode Adolescent-Onset Schizophrenia.
Article in The international journal of neuropsychopharmacology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers, 5 of them syntheses that pooled it.
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Who cites it
31 citing papers in PubMed, 5 syntheses or guidelines pooled it, 56 citations in OpenAlex.
- Processing Speed Impairment in Schizophrenia: An Updated Systematic Review and Meta-Analysis.JAMA psychiatry · 2026Pooled it
- Magnetic resonance imaging-based machine learning classification of schizophrenia spectrum disorders: a meta-analysis.Psychiatry and clinical neurosciences · 2024Pooled it
- Towards a brain-based predictome of mental illness.Human brain mapping · 2020Pooled it
- Advancing study of cognitive impairments for antipsychotic-naïve psychosis comparing high-income versus low- and middle-income countries with a focus on urban China: Systematic review of cognition and study methodology.Schizophrenia research · 2020Pooled it
- Application of Support Vector Machine on fMRI Data as Biomarkers in Schizophrenia Diagnosis: A Systematic Review.Frontiers in psychiatry · 2020Pooled it
- Schizophrenia and Neurodevelopment: Insights From Connectome Perspective.Schizophrenia bulletin · 2025Review
- miRNA-Based Diagnosis of Schizophrenia Using Machine Learning.International journal of molecular sciences · 2025Article
- Influence of depression severity on interhemispheric functional integration: an analysis from the REST-meta-MDD database.Brain imaging and behavior · 2025Article
- Association between homotopic connectivity and clinical symptoms in first-episode schizophrenia.Heliyon · 2024Article
- A new transfer entropy method for measuring directed connectivity from complex-valued fMRI data.Frontiers in neuroscience · 2024Article
- The role of the insula in cognitive impairment of schizophrenia.Schizophrenia research. Cognition · 2023Review
- Reduced homotopic interhemispheric connectivity in psychiatric disorders: evidence for both transdiagnostic and disorder specific features.Psychoradiology · 2022Review
- Neuroimaging biomarkers for detecting schizophrenia: A resting-state functional MRI-based radiomics analysis.Heliyon · 2022Article
- Alteration of a brain network with stable and strong functional connections in subjects with schizophrenia.Schizophrenia (Heidelberg, Germany) · 2022Article
- Abnormal global-brain functional connectivity and its relationship with cognitive deficits in drug-naive first-episode adolescent-onset schizophrenia.Brain imaging and behavior · 2022Article
- Machine Learning in Neuro-Oncology, Epilepsy, Alzheimer's Disease, and Schizophrenia.Acta neurochirurgica. Supplement · 2022Review
- Disrupted resting-state interhemispheric functional connectivity in systemic lupus erythematosus patients with and without neuropsychiatric lupus.Neuroradiology · 2022Article
- Resting-state electroencephalographic correlates of cognitive reserve: Moderating the age-related worsening in cognitive function.Frontiers in aging neuroscience · 2022Article
- Identifying and revealing different brain neural activities of cognitive subtypes in early course schizophrenia.Frontiers in molecular neuroscience · 2022Article
- Contributions of neuroimmune and gut-brain signaling to vulnerability of developing substance use disorders.Neuropharmacology · 2021Review
Corrections and comments
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Authors and funding
7 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Given that adolescence is a critical epoch in the onset of schizophrenia, studying aberrant brain changes in adolescent-onset schizophrenia, particularly in patients with drug-naive first-episode schizophrenia, is important to understand the biological mechanism of this disorder. Previous resting-state functional magnetic resonance imaging studies have shown abnormal functional connectivity in separate hemispheres in patients with adult-onset schizophrenia. Our aim to study adolescent-onset schizophrenia can provide clues for the early aetiology of schizophrenia. Method: A total of 48 drug-naïve, first-episode, adolescent-onset schizophrenia outpatients and 31 healthy controls underwent resting-state functional magnetic resonance imaging scans. Data were subjected to voxel-mirrored homotopic connectivity and support vector machine analyses. Results: Compared with the healthy controls, the adolescent-onset schizophrenia group showed significantly lower voxel-mirrored homotopic connectivity values in different brain regions, including the fusiform gyrus, superior temporal gyrus/insula, precentral gyrus, and precuneus. Decreased voxel-mirrored homotopic connectivity values in the superior temporal gyrus/insula were significantly correlated with Trail-Making Test: Part A performance (r = -0.437, P = .002). A combination of the voxel-mirrored homotopic connectivity values in the precentral gyrus and precuneus may be used to discriminate patients with adolescent-onset schizophrenia from controls with satisfactory classification results, which showed sensitivity of 100%, specificity of 87.09%, and accuracy of 94.93%. Conclusion: Our findings highlight resting-state interhemispheric FC abnormalities within the sensorimotor network of patients with adolescent-onset schizophrenia and confirm the relationship between adolescent-onset schizophrenia and adult-onset schizophrenia. These findings suggest that reduced interhemispheric connectivity within the sensorimotor network has a pivotal role in the pathogenesis of schizophrenia.
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