ArticlePloS one2017
Potential serum biomarkers and metabonomic profiling of serum in ischemic stroke patients using UPLC/Q-TOF MS/MS.
Article in PloS one, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers, 5 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
33 citing papers in PubMed, 5 syntheses or guidelines pooled it, 55 citations in OpenAlex.
- Systematic review and meta-analysis of stroke blood biomarker data highlights need for more translational research methods.Nature communications · 2026Pooled it
- Metabolomics reveals key biomarkers for ischemic stroke: a systematic review of emerging evidence.Frontiers in neurology · 2025Pooled it
- Pooled it
- Sex as a biological variable in determining the metabolic changes influencing acute ischemic stroke outcomes-Where is the data: A systematic review.Frontiers in neurology · 2022Pooled it
- Metabolomics facilitates the discovery of metabolic biomarkers and pathways for ischemic stroke: a systematic review.Metabolomics : Official journal of the Metabolomic Society · 2019Pooled it
- Metabolomics of Aerobic Exercise in Chronic Stroke Survivors: A Pilot Study.Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association · 2019Trial
- Fecal metabolites as early-phase biomarkers and prediction panel for ischemic stroke.BMC microbiology · 2025Article
- Exploring Lysophosphatidylcholine as a Biomarker in Ischemic Stroke: The Plasma-Brain Disjunction.International journal of molecular sciences · 2024Article
- Body fluid multiomics in 3PM-guided ischemic stroke management: health risk assessment, targeted protection against health-to-disease transition, and cost-effective personalized approach are envisaged.The EPMA journal · 2024Review
- Unraveling Metabolic Changes following Stroke: Insights from a Urinary Metabolomics Analysis.Metabolites · 2024Article
- Seeking understanding and action for the neurologic consequences of SARS-CoV-2 infection.Brain, behavior, and immunity · 2024Article
- Combining systems pharmacology, metabolomics, and transcriptomics to reveal the mechanism of Salvia miltiorrhiza-Cortex moutan herb pair for the treatment of ischemic stroke.Frontiers in pharmacology · 2024Article
- Metabolomics (Non-Targeted) of Induced Type 2 Diabetic Sprague Dawley Rats Comorbid with a Tissue-Dwelling Nematode Parasite.International journal of molecular sciences · 2023Article
- Preliminary insights on the metabolomics ofFrontiers in molecular biosciences · 2023Article
- Metabolomics of ischemic stroke: insights into risk prediction and mechanisms.Metabolic brain disease · 2022Review
- Global Metabolomic Profiling Reveals Disrupted Lipid and Amino Acid Metabolism Between the Acute and Chronic Stages of Ischemic Stroke.Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association · 2022Article
- Metabolomics as a potential tool for monitoring patients with aneurysmal subarachnoid hemorrhage.Frontiers in neurology · 2022Review
- Screening of Phospholipids in Plasma of Large-Artery Atherosclerotic and Cardioembolic Stroke Patients With Hydrophilic Interaction Chromatography-Mass Spectrometry.Frontiers in molecular biosciences · 2022Article
- Involvement of Ceramide Metabolism in Cerebral Ischemia.Frontiers in molecular biosciences · 2022Review
- Exploring potential serum levels of Homocysteine, interleukin-1 beta, and apolipoprotein B 48 as new biomarkers for patients with ischemic stroke.Journal of clinical laboratory analysis · 2021Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundStroke still has a high incidence with a tremendous public health burden and it is a leading cause of mortality and disability. However, biomarkers for early diagnosis are absent and the metabolic alterations associated with ischemic stroke are not clearly understood. The objectives of this case-control study are to identify serum biomarkers and explore the metabolic alterations of ischemic stroke.
methodsMetabonomic analysis was performed using ultra-performance liquid chromatography quadrupole time-of-flight tandem mass spectrometry and multivariate statistical analysis was employed to study 60 patients with or without ischemic stroke (30 cases and 30 controls).
resultsSerum metabolic profiling identified a series of 12 metabolites with significant alterations, and the related metabolic pathways involved glycerophospholipid, sphingolipid, phospholipid, fat acid, acylcarnitine, heme, and purine metabolism. Subsequently, multiple logistic regression analyses of these metabolites showed uric acid, sphinganine and adrenoyl ethanolamide were potential biomarkers of ischemic stroke with an area under the receiver operating characteristic curve of 0.941.
conclusionsThese findings provide insights into the early diagnosis and potential pathophysiology of ischemic stroke.
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