ArticlePloS one2017
Loci and pathways associated with uterine capacity for pregnancy and fertility in beef cattle.
Article in PloS one, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
34 citing papers in PubMed, 61 citations in OpenAlex.
- Extracellular vesicles in bovine reproduction: their journey from gametogenesis to pregnancy.Frontiers in cell and developmental biology · 2026Review
- Validation of loci and genes associated with fertility in Holstein cows using gene-set enrichment analysis-SNP and genotype-by-sequencing.BMC genomics · 2025Article
- Genomic study for pregnancy loss in Brahman cattle.Journal of animal science · 2025Article
- Article
- Weighted single-step genome-wide association study for direct and maternal genetic effects associated with birth and weaning weights in sheep.Scientific reports · 2024Article
- Exploration of the Polymorphism Distribution of BovineAnimals : an open access journal from MDPI · 2024Article
- Abortion associated with postpartum opportunistic bacterial invasion reduces fertility and induces disturbances of reproductive hormones, hematological profile, and oxidant/antioxidant profiles in dairy cows.Journal of advanced veterinary and animal research · 2023Article
- Identification of quantitative trait loci and associated candidate genes for pregnancy success in Angus-Brahman crossbred heifers.Journal of animal science and biotechnology · 2023Article
- Harnessing Genomics and Transcriptomics Approaches to Improve Female Fertility in Beef Cattle-A Review.Animals : an open access journal from MDPI · 2023Review
- Genome-wide scan for runs of homozygosity in South American Camelids.BMC genomics · 2023Article
- A multi-omics analysis identifies molecular features associated with fertility in heifers (Bos taurus).Scientific reports · 2023Article
- Article
- Constraint-Based, Score-Based and Hybrid Algorithms to Construct Bayesian Gene Networks in the Bovine Transcriptome.Animals : an open access journal from MDPI · 2022Article
- Progesterone differentially affects the transcriptomic profiles of cow endometrial cell types.BMC genomics · 2022Article
- Genome-Wide Selection Signatures and Human-Mediated Introgression Events inFrontiers in genetics · 2022Article
- Genome-Wide Association Study Provides Insights into Important Genes for Reproductive Traits in Nelore Cattle.Animals : an open access journal from MDPI · 2021Article
- Conceptus metabolomic profiling reveals stage-specific phenotypes leading up to pregnancy recognition in cattle†.Biology of reproduction · 2021Article
- Identification of markers associated with estimated breeding value and horn colour in Hungarian Grey cattle.Animal bioscience · 2021Article
- Article
- Identification of Genomic Regions Influencing N-Metabolism and N-Excretion in Lactating Holstein- Friesians.Frontiers in genetics · 2021Article
Corrections and comments
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Authors and funding
7 authors at 4 institutions in 1 country.
Funding
Abstract
Infertility and subfertility negatively impact the economics and reproductive performance of cattle. Of note, significant pregnancy loss occurs in cattle during the first month of pregnancy, yet little is known about the genetic loci influencing pregnancy success and loss in cattle. To identify quantitative trait loci (QTL) with large effects associated with early pregnancy loss, Angus crossbred heifers were classified based on day 28 pregnancy outcomes to serial embryo transfer. A genome wide association analysis (GWAA) was conducted comparing 30 high fertility heifers with 100% success in establishing pregnancy to 55 subfertile heifers with 25% or less success. A gene set enrichment analysis SNP (GSEA-SNP) was performed to identify gene sets and leading edge genes influencing pregnancy loss. The GWAA identified 22 QTL (p < 1 x 10-5), and GSEA-SNP identified 9 gene sets (normalized enrichment score > 3.0) with 253 leading edge genes. Network analysis identified TNF (tumor necrosis factor), estrogen, and TP53 (tumor protein 53) as the top of 671 upstream regulators (p < 0.001), whereas the SOX2 (SRY [sex determining region Y]-box 2) and OCT4 (octamer-binding transcription factor 4) complex was the top master regulator out of 773 master regulators associated with fertility (p < 0.001). Identification of QTL and genes in pathways that improve early pregnancy success provides critical information for genomic selection to increase fertility in cattle. The identified genes and regulators also provide insight into the complex biological mechanisms underlying pregnancy establishment in cattle.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.