Evidence map›Paper›PMID 29227833›Full record

ArticleThe Journal of nutritional biochemistry2018

Vitamin A deficiency in mice alters host and gut microbial metabolism leading to altered energy homeostasis.

Yuan Tian, Robert G Nichols, Jingwei Cai, Andrew D Patterson, Margherita T Cantorna

Abstract read
In one paragraph

Article in The Journal of nutritional biochemistry, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
43citing papers in PubMed, 1 pooled it
3.7field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

43 citing papers in PubMed, 1 synthesis or guideline pooled it, 73 citations in OpenAlex.

  1. Pooled it
  2. Trial
  3. Epithelial sensing of vitamin A shapes intestinal antimicrobial defense.bioRxiv : the preprint server for biology · 2026
    Article
  4. Article
  5. Article
  6. Article
  7. Review
  8. Gut microbiota, nutrients, and depression.Frontiers in nutrition · 2025
    Review
  9. Article
  10. Article
  11. Article
  12. Review
  13. Review
  14. Review
  15. [Vitamins and Immune System Health].Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition · 2023
    Review
  16. Review
  17. Article
  18. Article
  19. β-carotene improves fecal dysbiosis and intestinal dysfunctions in a mouse model of vitamin A deficiency.Biochimica et biophysica acta. Molecular and cell biology of lipids · 2022
    Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 2 countries.

Yuan TianDepartment of Veterinary and Biomedical Sciences, The Pennsylvania State University, University Park, PA 16802, United States; Department of Biochemistry and Molecular Biology, The Pennsylvania State University, University Park, PA 16802, United States; CAS Key Laboratory of Magnetic Resonance in Biological Systems, State Key Laboratory of Magnetic Resonance and Atomic and Molecular Physics, National Centre for Magnetic Resonance in Wuhan, Wuhan Institute of Physics and Mathematics, University of Chinese Academy of Sciences, Wuhan, 430071, China.
Robert G NicholsDepartment of Biochemistry and Molecular Biology, The Pennsylvania State University, University Park, PA 16802, United States.
Jingwei CaiDepartment of Biochemistry and Molecular Biology, The Pennsylvania State University, University Park, PA 16802, United States.
Andrew D PattersonDepartment of Veterinary and Biomedical Sciences, The Pennsylvania State University, University Park, PA 16802, United States; Department of Biochemistry and Molecular Biology, The Pennsylvania State University, University Park, PA 16802, United States.
Margherita T CantornaDepartment of Veterinary and Biomedical Sciences, The Pennsylvania State University, University Park, PA 16802, United States. Electronic address: mxc69@psu.edu.
Pennsylvania State University · US

Funding

Vitamin D Fluctuations and the Mucosal Immune ResponseR01AT005378 · NCCIH · PENNSYLVANIA STATE UNIVERSITY, THE · PI CANTORNA, MARGHERITA T · 2009 to 2020
$4.1M
Penn State Biomedical Big Data to Knowledge (B2D2K) Training ProgramT32LM012415 · NLM · PENNSYLVANIA STATE UNIVERSITY, THE · PI BROACH, JAMES R., HONAVAR, VASANT G. · 2016 to 2020
$1.2M
Vitamin A mediated protection from gastrointestinal infectionR56AI114972 · NIAID · PENNSYLVANIA STATE UNIVERSITY, THE · PI CANTORNA, MARGHERITA T, ROSS, A. CATHARINE · 2015 to 2015
$477k
NCCIH NIH HHS R01 AT005378NIAID NIH HHS R56 AI114972NLM NIH HHS T32 LM012415
6 · The paper itself

Abstract

Vitamin A deficiency (A-) is a worldwide public health problem. To better understand how vitamin A status influences gut microbiota and host metabolism, we systematically analyzed urine, cecum, serum and liver samples from vitamin A sufficient (A+) and deficient (A-) mice using

Indexed as

AnimalsBody WeightEnergy MetabolismFemaleGastrointestinal MicrobiomeGlucose Tolerance TestMagnetic Resonance SpectroscopyMaleMice, Inbred C57BLRNA, Ribosomal, 16SVitamin A DeficiencyRNA, Ribosomal, 16SDiabetesMetabolomicsMicrobiotaShort-chain fatty acidsVitamin A

Identifiers

PMID29227833
PMCPMC5866754
OpenAlexW2765991442

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.