Evidence map›Paper›PMID 29227355›Full record

ReviewCurrent opinion in rheumatology2018

Basic calcium phosphate crystal-associated musculoskeletal syndromes: an update.

Ann K Rosenthal

Abstract readReview
In one paragraph

Review in Current opinion in rheumatology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
2.0field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 40 citations in OpenAlex.

  1. Observational
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  7. Comparative review: clinical and pathological heterogeneity in kneeFrontiers in bioengineering and biotechnology · 2025
    Review
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  12. Article
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  15. Article
  16. Calcium crystal deposition diseases - beyond gout.Nature reviews. Rheumatology · 2018
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

1 author at 1 institution in 1 country.

Ann K RosenthalDepartment of Medicine, Division of Rheumatology, Medical College of Wisconsin.
GTx (United States) · US

Funding

ANK-dependent ATP efflux causes calcium pyrophosphate deposition in cartilageI01CX001143 · VA · CLEMENT J. ZABLOCKI VA MEDICAL CENTER · PI ROSENTHAL, ANN K · 2015 to 2018
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CSRD VA I01 CX001143
6 · The paper itself

Abstract

purpose of reviewBasic calcium phosphate (BCP) crystals are associated with two important musculoskeletal syndromes. Deposition of BCP crystals in tendons, bursae, and other soft tissues around joints causes calcific periarthritis, whereas intra-articular BCP crystals contribute to osteoarthritis and cause the highly destructive arthritis known as Milwaukee Shoulder Syndrome. The epidemiology and natural history of these syndromes are poorly understood, and because the pathogenesis remains unclear, few targeted therapies are available. I will review new developments in this field. RECENT

findingsI will discuss a case collection of calcific periarthritis of the hip, and evidence-based management strategies for shoulder calcific periarthritis that might be applied to calcific periarthritis at other locations. I will summarize several recent articles addressing mechanisms of crystal formation and identifying pathways through which BCP crystals produce tissue damage and explore some newly identified risk factors for pathologic mineralization. SUMMARY: We are making slow, but steady progress in understanding the clinical presentation of calcific periarthritis in sites other than the shoulder. A growing appreciation of the mechanisms through which BCP crystals mediate tissue damage should lead to the development of novel management strategies for these common musculoskeletal syndromes.

Indexed as

CalcinosisCalcium PhosphatesCrystal ArthropathiesHumansMusculoskeletal DiseasesOsteoarthritisSyndromeCalcium Phosphates

Identifiers

PMID29227355
PMCPMC6241512
OpenAlexW2772840954

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.