Evidence map›Paper›PMID 29227353›Full record

ReviewCurrent opinion in rheumatology2018

Epidemiology of osteoarthritis: literature update.

Ernest R Vina, C Kent Kwoh

Registry-linked trialAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Current opinion in rheumatology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07313020 (A Visualization Clinical Study Using a Handheld MPI Imaging Device for Monitoring Mesenchymal Stromal Cells in Osteoarthritis Treatment), which is not on this map. Cited by 487 papers, 9 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
487citing papers in PubMed, 9 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07313020 early_phase1enrolling by invitationnot on this mapstarted 2025, after this paper: background citation

A Visualization Clinical Study Using a Handheld MPI Imaging Device for Monitoring Mesenchymal Stromal Cells in Osteoarthritis Treatment

TypeinterventionalSponsorSoochow UniversityRan2025 to 2026Enrolled10ConditionsKnee Arthritis OsteoarthritisArmsHuman Umbilical Cord-derived Mesenchymal Stromal Cells (hUC-MSCs), Ferumoxytol (SPIO) Solution for Injection (Placebo)
3 · Its place in the literature

Who cites it

487 citing papers in PubMed, 9 syntheses or guidelines pooled it.

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  6. Cryotherapy in Knee Osteoarthritis: A Systematic Review With Meta-Analysis.Pain practice : the official journal of World Institute of Pain · 2025
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427 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Ernest R VinaDivision of Rheumatology, Department of Medicine.
C Kent KwohDivision of Rheumatology, Department of Medicine.

Funding

Risk of Incident Knee OA & Clinical Outcomes Based on Imaging BiomarkersR01AR066601 · NIAMS · UNIVERSITY OF ARIZONA · PI GUERMAZI, ALI, KWOH, C KENT · 2014 to 2018
$6.2M
Quality and Equity in Osteoarthritis: Understanding & Improving Treatment UseK23AR067226 · NIAMS · UNIVERSITY OF ARIZONA · PI VINA, ERNEST R · 2015 to 2019
$834k
NIAMS NIH HHS K23 AR067226NIAMS NIH HHS R01 AR066601
6 · The paper itself

Abstract

purpose of reviewThe purpose of this review is to highlight recent studies of osteoarthritis epidemiology, including research on prevalence, disease impact, and potential risk factors. RECENT

findingsOsteoarthritis is highly prevalent in the United States and around the globe. It is a leading cause of disability and can negatively impact people's physical and mental well being. Healthcare resources and costs associated with managing the disease can be substantial. There is increasing evidence that there are different osteoarthritis phenotypes that reflect different mechanisms of the disease. Various person-level risk factors are recognized, including sociodemographic characteristics (e.g. female sex, African-American race), genetic predispositions, obesity, diet-related factors, and high bone density/mass. Joint-level risk factors include specific bone/joint shapes, thigh flexor muscle weakness, joint malalignment, participation in certain occupational/sports activities, and joint injury. Recent studies have enhanced our understanding of preradiographic lesions associated with osteoarthritis. SUMMARY: Application of these new findings may allow us to develop innovative strategies and novel therapies with the purpose of preventing new disease onset and minimizing disease progression.

Indexed as

Cost of IllnessDisease ProgressionHumansOsteoarthritisPhenotypePrevalenceRisk FactorsUnited States

Identifiers

PMID29227353
PMCPMC5832048

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.