Evidence map›Paper›PMID 29227247›Full record

ArticleeLife2017

Stress-induced Cdk5 activity enhances cytoprotective basal autophagy in

Nilay Nandi, Lauren K Tyra, Drew Stenesen, Helmut Krämer

Erratum issuedOpen access · goldAbstract read
In one paragraph

Article in eLife, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 27 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed, 1 pooled it
1.7field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

27 citing papers in PubMed, 1 synthesis or guideline pooled it, 35 citations in OpenAlex.

  1. Guideline
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  7. bioRxiv : the preprint server for biology · 2024
    Article
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  13. Article
  14. Protein modification regulated autophagy inFrontiers in physiology · 2023
    Review
  15. Bio-protocol · 2022
    Article
  16. Article
  17. Article
  18. Article
  19. Review
  20. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Nilay NandiDepartment of Neuroscience, UT Southwestern Medical Center, Dallas, United States.ORCID http://orcid.org/0000-0002-7088-4943
Lauren K TyraDepartment of Neuroscience, UT Southwestern Medical Center, Dallas, United States.
Drew StenesenDepartment of Neuroscience, UT Southwestern Medical Center, Dallas, United States.
Helmut KrämerDepartment of Neuroscience, UT Southwestern Medical Center, Dallas, United States.ORCID http://orcid.org/0000-0002-1167-2676
Southwestern Medical Center · US

Funding

Resource Component: Acquisition, maintenance and distribution of Drosophila stocksP40OD018537 · OD · TRUSTEES OF INDIANA UNIVERSITY · PI Annette L. Parks · 2014 to 2026
$13.5M
MOLECULAR ANALYSIS OF THE BOSS TRANSMEMBRANE LIGANDR01EY010199 · NEI · UT SOUTHWESTERN MEDICAL CENTER · PI Helmut J Kramer · 1994 to 2026
$9.7M
SEM for UT Southwestern EM Core FacilityS10OD020103 · OD · UT SOUTHWESTERN MEDICAL CENTER · PI LUBY-PHELPS, KATHERINE J · 2015 to 2015
$306k
NEI NIH HHS R01 EY010199NIH HHS P40 OD018537NIH HHS S10 OD020103
6 · The paper itself

Abstract

Cdk5 is a post-mitotic kinase with complex roles in maintaining neuronal health. The various mechanisms by which Cdk5 inhibits and promotes neurodegeneration are still poorly understood. Here, we show that in

Indexed as

AutophagyProtein Processing, Post-TranslationalAmino Acid SubstitutionAnimalsCyclin-Dependent Kinase 5Drosophila melanogasterDrosophila ProteinsMutagenesis, Site-DirectedPhosphorylationProtein Interaction MappingTranscription FactorsAcn protein, DrosophilaCdk5 protein, DrosophilaCyclin-Dependent Kinase 5Drosophila ProteinsTranscription Factorsautophagycell biologycompound eyeD. melanogasterDrosophilafat bodyneurodegeneration

Identifiers

PMID29227247
PMCPMC5760206
OpenAlexW2773715489

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.