ArticleThe clinical respiratory journal2018
Blood biomarkers as predictors of long-term mortality in COPD.
Article in The clinical respiratory journal, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
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Who cites it
33 citing papers in PubMed, 61 citations in OpenAlex.
- Article
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- The clinical usefulness of neutrophil percentage/albumin ratio in predicting the one-month mortality in chronic obstructive pulmonary disease patients hospitalized with community-acquired pneumonia.BMC pulmonary medicine · 2025Article
- Development and validation a nomogram to predict long-term mortality risks of PRISm and mild-to-moderate COPD based on NHANES 2007-2012.Scientific reports · 2025Article
- What every clinician should know about inflammation in COPD.ERJ open research · 2024Review
- Epigenetic age acceleration and mortality risk prediction in U.S. adults.medRxiv : the preprint server for health sciences · 2024Article
- Article
- The cGAS-STING pathway in COPD: targeting its role and therapeutic potential.Respiratory research · 2024Review
- Inflammation as the nexus: exploring the link between acute myocardial infarction and chronic obstructive pulmonary disease.Frontiers in cardiovascular medicine · 2024Review
- Hematological Parameters for Predicting Mortality in Acute Exacerbation of Chronic Obstructive Pulmonary Disease.Journal of clinical medicine · 2023Article
- [Association between vitamin D level and blood eosinophil count in healthy population and patients with chronic obstructive pulmonary disease].Nan fang yi ke da xue xue bao = Journal of Southern Medical University · 2023Article
- Clinical Implications of Low Absolute Blood Eosinophil Count in the SPIROMICS COPD Cohort.Chest · 2023Article
- Prognostic Value of Neutrophil to Lymphocyte Ratio for Predicting 90-Day Poor Outcomes in Hospitalized Patients with Acute Exacerbation of Chronic Obstructive Pulmonary Disease.International journal of chronic obstructive pulmonary disease · 2023Article
- Relationship between human serum albumin and in-hospital mortality in critical care patients with chronic obstructive pulmonary disease.Frontiers in medicine · 2023Article
- Blood volatile organic compounds associated with non-reversible and reversible airflow obstruction in US adults.The European respiratory journal · 2022Article
- Comorbidities in childhood-onset and adult-onset asthma.Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology · 2022Article
- Serum antioxidant vitamins and respiratory morbidity and mortality: a pooled analysis.Respiratory research · 2022Article
- Biochemical clusters predict mortality and reported inability to work 10 years later.Brain, behavior, & immunity - health · 2022Article
- The mechanistic role of neutrophil lymphocyte ratio perturbations in the leading non communicable lifestyle diseases.F1000Research · 2022Review
- Blood eosinophil count-guided corticosteroid therapy and as a prognostic biomarker of exacerbations of chronic obstructive pulmonary disease: a systematic review and meta-analysis.Therapeutic advances in chronic disease · 2021Article
Corrections and comments
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Authors and funding
4 authors at 4 institutions in 3 countries.
Funding
Abstract
backgroundBlood biomarkers are easily accessible and might reflect chronic obstructive pulmonary disease (COPD) activity.
aimThe aim of this study was to determine whether a panel of blood biomarkers [C-reactive protein (CRP), neutrophils, eosinophils, albumin and vitamin D] could predict mortality in COPD.
methodsWe analyzed data from 431 COPD participants to the 2007-2010 National Health and Nutrition Examination Surveys who were followed for a median time of 36 months. COPD was defined as post-bronchodilator forced expiratory volume in 1 second (FEV1) and forced vital capacity ratio <0.70. Weibull survival analysis adjusted for covariates was performed to calculate the risk of mortality associated with the biomarkers, and C-statistics was used to assess their added predictive value.
resultsDuring follow-up, 38 of the 431 participants died. Participants with high CRP, eosinophil count <2%, hypoalbuminemia and hypovitaminosis D had worse baseline FEV1 and subsequently higher mortality compared to controls. In adjusted analysis, increasing CRP [hazard ratio (HR): 4.45, 95% CI: 1.91-10.37] and neutrophil count (HR: 1.07, 95% CI: 1.03-1.11) as well as decreasing eosinophil count (HR: 7.03, 95% CI: 2.05-24.01) were associated with an increased risk of mortality. The addition of CRP with eosinophil and/or neutrophil count significantly improved a base model for the prediction of mortality which included age, gender, race/ethnicity, body mass index, smoking, poverty income ratio, asthma, diabetes, hypertension and history of stroke or myocardial infarction.
conclusionHigh CRP and neutrophils as well as low eosinophils are predictive of poor COPD prognosis. They also add significant value to prediction models of mortality in COPD.
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