ArticleMolecular plant pathology2018
The GATA-type IVb zinc-finger transcription factor SsNsd1 regulates asexual-sexual development and appressoria formation in Sclerotinia sclerotiorum.
Article in Molecular plant pathology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.
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37 citing papers in PubMed, 68 citations in OpenAlex.
- Effects of an Isolate ofPlants (Basel, Switzerland) · 2026Article
- Sspdhx Related to the Development and Virulence of Sclerotinia sclerotiorum Represents a Potential RNAi Target for Controlling Sclerotinia Disease.Molecular plant pathology · 2026Article
- BdAreA regulates nitrogen metabolism, stress response, and virulence in Botryosphaeria dothidea.Crop health · 2026Article
- Revealing the early pathogenic mechanisms of Agroatehlia rolfsii in Arachis hypogaea through RNA-seq and identification of ArNIS1-like effectors.BMC plant biology · 2026Article
- A Guide to Culturing, Maintenance, and Leaf Inoculation Methods for Rapid Screening and Quantification of Sclerotinia sclerotiorum Infection in Mustard.Methods in molecular biology (Clifton, N.J.) · 2026Article
- Inoculum and inoculation techniques: key steps in studying pathogenicity and resistance to Sclerotinia stem rot in oilseed rape.Frontiers in plant science · 2025Review
- A Virulence Factor fromPlants (Basel, Switzerland) · 2024Article
- The Transcription Factor SsZNC1 Mediates Virulence, Sclerotial Development, and Osmotic Stress Response inJournal of fungi (Basel, Switzerland) · 2024Article
- The schizotrophic lifestyle of Sclerotinia sclerotiorum.Molecular plant pathology · 2024Review
- Recent advances in virulence of a broad host range plant pathogenFrontiers in microbiology · 2024Review
- The secreted FolAsp aspartic protease facilitates the virulence ofFrontiers in microbiology · 2023Article
- The Role of Chromatin and Transcriptional Control in the Formation of Sexual Fruiting Bodies in Fungi.Microbiology and molecular biology reviews : MMBR · 2022Review
- Article
- An Amidase Contributes to Full Virulence ofInternational journal of molecular sciences · 2022Article
- Functional Characterization of the GATA-Type Transcription Factor PaNsdD in the Filamentous Fungus Podospora anserina and Its Interplay with the Sterigmatocystin Pathway.Applied and environmental microbiology · 2022Article
- The Coupling Between Cell Wall Integrity Mediated by MAPK Kinases and SsFkh1 Is Involved in Sclerotia Formation and Pathogenicity ofFrontiers in microbiology · 2022Article
- Role of Dicer-Dependent RNA Interference in Regulating Mycoparasitic Interactions.Microbiology spectrum · 2021Article
- ε-poly-Journal of fungi (Basel, Switzerland) · 2021Article
- Diversity and Function of Appressoria.Pathogens (Basel, Switzerland) · 2021Review
- Article
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Authors and funding
7 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The sclerotium, a multicellular structure composed of the compact aggregation of vegetative hyphae, is critical for the long-term survival and sexual reproduction of the plant-pathogenic fungus Sclerotinia sclerotiorum. The development and carpogenic germination of sclerotia are regulated by integrating signals from both environmental and endogenous processes. Here, we report the regulatory functions of the S. sclerotiorum GATA-type IVb zinc-finger transcription factor SsNsd1 in these processes. SsNsd1 is orthologous to the Aspergillus nidulans NsdD (never in sexual development) and the Neurospora crassa SUB-1 (submerged protoperithecia-1) proteins. Ssnsd1 gene transcript accumulation remains relatively low, but variable, during vegetative mycelial growth and multicellular development. Ssnsd1 deletion mutants (Δnsd1-KOs) produce phialides and phialospores (spermatia) excessively in vegetative hyphae and promiscuously within the interior medulla of sclerotia. In contrast, phialospore development occurs only on the sclerotium surface in the wild-type. Loss of SsNsd1 function affects sclerotium structural integrity and disrupts ascogonia formation during conditioning for carpogenic germination. As a consequence, apothecium development is abolished. The Ssnsd1 deletion mutants are also defective in the transition from hyphae to compound appressorium formation, resulting in a loss of pathogenicity on unwounded hosts. In sum, our results demonstrate that SsNsd1 functions in a regulatory role similar to its ascomycete orthologues in regulating sexual and asexual development. Further, SsNsd1 appears to have evolved as a regulator of pre-penetration infectious development required for the successful infection of its many hosts.
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