ArticleThe New phytologist2018
A dominant-interfering camta3 mutation compromises primary transcriptional outputs mediated by both cell surface and intracellular immune receptors in Arabidopsis thaliana.
Article in The New phytologist, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.
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Who cites it
35 citing papers in PubMed, 98 citations in OpenAlex.
- Article
- Humidity-driven ABA depletion determines plant-pathogen competition for leaf water.Nature communications · 2025Article
- Overexpression of the Receptor-Like Kinase BIR1 Causes SOBIR1- and EDS1-Dependent Cell Death Phenotypes in Arabidopsis.Plant, cell & environment · 2025Article
- The resistance awakens: Diversity at the DNA, RNA, and protein levels informs engineering of plant immune receptors from Arabidopsis to crops.The Plant cell · 2025Review
- A rare PRIMER cell state in plant immunity.Nature · 2025Article
- Transcriptomic Analysis Reveals the Opposite Regulatory Effects of WRKY and CAMTA Transcription Factors on Total Tannin Production inInternational journal of molecular sciences · 2024Article
- CAMTA3 repressor destabilization triggers TIR domain protein TN2-mediated autoimmunity in the Arabidopsis exo70B1 mutant.The Plant cell · 2024Article
- Plant NLR immunity activation and execution: a biochemical perspective.Open biology · 2024Review
- NLR- andPlants (Basel, Switzerland) · 2023Review
- Transcriptomic Analysis Revealed Key Defense Genes and Signaling Pathways Mediated by theInternational journal of molecular sciences · 2023Article
- Plant immune receptor pathways as a united front against pathogens.PLoS pathogens · 2023Article
- An Overview of PRR- and NLR-Mediated Immunities: Conserved Signaling Components across the Plant Kingdom That Communicate Both Pathways.International journal of molecular sciences · 2022Review
- What's new in protein kinase/phosphatase signalling in the control of plant immunity?Essays in biochemistry · 2022Review
- PAMP-triggered genetic reprogramming involves widespread alternative transcription initiation and an immediate transcription factor wave.The Plant cell · 2022Article
- Con-CaThe New phytologist · 2022Review
- Thirty years of resistance: Zig-zag through the plant immune system.The Plant cell · 2022Review
- Calcium channels and transporters: Roles in response to biotic and abiotic stresses.Frontiers in plant science · 2022Review
- Simultaneous Ozone and High Light Treatments Reveal an Important Role for the Chloroplast in Co-ordination of Defense Signaling.Frontiers in plant science · 2022Article
- Perception of structurally distinct effectors by the integrated WRKY domain of a plant immune receptor.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- How activated NLRs induce anti-microbial defenses in plants.Biochemical Society transactions · 2021Review
Corrections and comments
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Authors and funding
9 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Pattern recognition receptors (PRRs) and nucleotide-binding domain and leucine-rich repeat (LRR)-containing proteins (NLRs) initiate pattern-triggered immunity (PTI) and effector-triggered immunity (ETI), respectively, each associated with the activation of an overlapping set of defence genes. The regulatory mechanism behind this convergence of PTI- and ETI-mediated defence gene induction remains elusive. We generated transgenic Arabidopsis plants that enable conditional NLR activation without pathogen infection to dissect NLR- and PRR-mediated transcriptional signals. A comparative analysis of over 40 transcriptome datasets linked calmodulin-binding transcription activators (CAMTAs) to the activation of overlapping defence genes in PTI and ETI. We used a dominant camta3 mutant (camta3-D) to assess CAMTA functions in the corresponding transcriptional regulation. Transcriptional regulation by NLRs, although highly similar to PTI responses, can be established independently of pathogen-associated molecular pattern (PAMP) perception, defence phytohormones and host cell death. Conditional expression of the N-terminal coiled-coil domain of the barley MLA (Mildew resistance locus A) NLR is sufficient to trigger similar transcriptional reprogramming as full-length NLRs. CAMTA-binding motifs are overrepresented in the 5' regulatory regions of the identified primary immune response genes, consistent with their altered expression and disease resistance responses in camta3-D plants. We propose that CAMTA-mediated transcriptional regulation defines an early convergence point in NLR- and PRR-mediated signalling.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.