Evidence map›Paper›PMID 29226740›Full record

ArticleThe journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians2019

Do infants in the neonatal intensive care unit diagnosed with urinary tract infection need a routine voiding cystourethrogram?

Dustin D Flannery, Erik Brandsma, Judy Saslow, Amy B Mackley, David A Paul, Zubair H Aghai

Open access · greenAbstract read
In one paragraph

Article in The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed, 1 pooled it
0.8field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 1 synthesis or guideline pooled it, 8 citations in OpenAlex.

  1. Treatment of positive urine cultures in the neonatal intensive care unit: a guideline to reduce antibiotic utilization.Journal of perinatology : official journal of the California Perinatal Association · 2021
    Guideline
  2. Observational
  3. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors at 4 institutions in 1 country.

Dustin D Flannerya Division of Neonatology , The Children's Hospital of Philadelphia , Philadelphia , PA , USA.
Erik Brandsmaa Division of Neonatology , The Children's Hospital of Philadelphia , Philadelphia , PA , USA.
Judy Saslowb Division of Neonatology , Cooper University Hospital , Camden , NJ , USA.
Amy B Mackleyc Division of Neonatology , Christiana Care Health System , Newark , DE , USA.
David A Paulc Division of Neonatology , Christiana Care Health System , Newark , DE , USA.
Zubair H Aghaid Division of Neonatology , Thomas Jefferson University Hospital/Nemours , Philadelphia , PA , USA.
Children's Hospital of Philadelphia · USChristiana Care Health System · USCooper University Hospital · USThomas Jefferson University Hospital · US

Funding

Subproject Title: Clinical Research Education, Mentoring and Career Development CoreU54GM104941 · NIGMS · UNIVERSITY OF DELAWARE · PI Gregory E Hicks · 2013 to 2026
$60.5M
Pediatric Hospital Epidemiology and Outcomes Research Training ProgramT32HD060550 · NICHD · CHILDREN'S HOSP OF PHILADELPHIA · PI Christopher Peter Bonafide, John Chris Feudtner · 2010 to 2026
$6.8M
Center for Pediatric Research Pilot ProgramP30GM114736 · NIGMS · NEMOURS CHILDREN'S HOSPITAL, DELAWARE · PI SHAFFER, THOMAS H · 2015 to 2019
$5.1M
NICHD NIH HHS T32 HD060550NIGMS NIH HHS P30 GM114736NIGMS NIH HHS U54 GM104941
6 · The paper itself

Abstract

objectiveTo determine if infants diagnosed with urinary tract infection (UTI) in the neonatal intensive care unit (NICU) require a routine voiding cystourethrogram (VCUG). STUDY

designRetrospective data analysis from three centers for infants admitted to the NICU born between 2000 and 2013 and diagnosed with UTI.

resultsOne hundred twenty-six infants from three centers were diagnosed with UTI during their hospitalization. Renal ultrasound (RUS) was performed in 115 infants (91.2%), of which 69 (60%) were abnormal. Mild to moderate hydronephrosis or pelviectasis were the most common abnormalities identified (n = 34, 30%). There were 14 infants (12%) with severe abnormalities on RUS. VCUG was performed in 71 infants (56%), of which 3 (4%) were interpreted as abnormal with grade 2 vesicoureteral reflux (VUR) or less (two infants were with normal RUS and one infant was with abnormal RUS).

conclusionsMore than 50% of infants with a UTI had an abnormal RUS but severe abnormalities were found only in 11% of infants. Only 4% of infants with UTI had VUR; none of these infants had severe VUR on VCUG. A routine VCUG after UTI in the NICU has a low yield and may be reserved for infants with severe or persistent abnormalities on RUS.

Indexed as

FemaleHumansInfant, NewbornIntensive Care Units, NeonatalMaleRetrospective StudiesUnnecessary ProceduresUrinary Tract InfectionsUrographyNeonaterenal ultrasoundurinary tract infectionvesicoureteral refluxvoiding cystourethrogram

Identifiers

PMID29226740
PMCPMC6013341
OpenAlexW2775266079

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.