Evidence map›Paper›PMID 29226628›Full record

ArticlePharmacology research & perspectives2017

Modeling of prolactin response following dopamine D

Amit Taneja, An Vermeulen, Dymphy R H Huntjens, Meindert Danhof, Elizabeth C M De Lange, Johannes H Proost

Open access · goldAbstract readComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Pharmacology research & perspectives, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.2field-weighted citation impact, top 43% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 2 citations in OpenAlex.

  1. Article
  2. Modeling of prolactin response following dopamine DPharmacology research & perspectives · 2017
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 2 countries.

Amit TanejaDivision of Pharmacokinetics, Toxicology and Targeting, Groningen Research Institute of Pharmacy, University of Groningen, Antonius Deusinglaan 1, 9713 AV, Groningen, The Netherlands.
An VermeulenDivision of Janssen Pharmaceutica NV, Clinical Pharmacology and Pharmacometrics, Janssen Research and Development, Beerse, Belgium.
Dymphy R H HuntjensDivision of Janssen Pharmaceutica NV, Clinical Pharmacology and Pharmacometrics, Janssen Research and Development, Beerse, Belgium.
Meindert DanhofDepartment of Pharmacology, Leiden Academic Center for Drug Research, Leiden University, Leiden, The Netherlands.
Elizabeth C M De LangeDepartment of Pharmacology, Leiden Academic Center for Drug Research, Leiden University, Leiden, The Netherlands.
Johannes H ProostDivision of Pharmacokinetics, Toxicology and Targeting, Groningen Research Institute of Pharmacy, University of Groningen, Antonius Deusinglaan 1, 9713 AV, Groningen, The Netherlands.ORCID 0000-0002-7155-783X
Janssen (Belgium) · BELeiden University · NLUniversity of Groningen · NL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Prolactin release is a side effect of antipsychotic therapy with dopamine antagonists, observed in rats as well as humans. We examined whether two semimechanistic models could describe prolactin response in rats and subsequently be translated to predict pituitary dopamine D

Indexed as

Models, BiologicalAnimalsDopamine D2 Receptor AntagonistsHumansMalePaliperidone PalmitateProlactinRatsRats, WistarRemoxiprideRisperidoneSoftwareDopamine D2 Receptor AntagonistsPaliperidone PalmitateProlactinRemoxiprideRisperidoneAgonist-antagonist interaction modeldopamine D2 antagonistsprecursor pool modelprolactinreceptor occupancytranslational modeling

Identifiers

PMID29226628
PMCPMC5723698
OpenAlexW2769546281

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.