Evidence map›Paper›PMID 29226621›Full record

ArticlePharmacology research & perspectives2017

Cenerimod, a novel selective S1P

Luca Piali, Magdalena Birker-Robaczewska, Cyrille Lescop, Sylvie Froidevaux, Nicole Schmitz, Keith Morrison, Christopher Kohl, Markus Rey, Rolf Studer, Enrico Vezzali and 5 more

Open access · goldAbstract read
In one paragraph

Article in Pharmacology research & perspectives, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed, 1 pooled it
1.2field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 1 synthesis or guideline pooled it, 30 citations in OpenAlex.

  1. Pooled it
  2. Trial
  3. Lack of Effect of Cenerimod, a Selective S1PInternational journal of molecular sciences · 2022
    Trial
  4. Trial
  5. Modelling pharmacokinetics and pharmacodynamics of the selective S1PBritish journal of clinical pharmacology · 2020
    Trial
  6. Trial
  7. Review
  8. Review
  9. Article
  10. Review
  11. In Vitro Characterization of Sphingosine 1-Phosphate Receptor 1 (S1PInternational journal of molecular sciences · 2022
    Article
  12. Cenerimod, a selective S1PArthritis research & therapy · 2021
    Article
  13. Review
  14. Article
  15. Review
  16. Article
  17. Review
  18. Article
  19. First use of cenerimod, a selective S1PLupus science & medicine · 2019
    Article
  20. Cenerimod, a novel selective S1PPharmacology research & perspectives · 2017
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 1 institution in 1 country.

Luca PialiIdorsia Pharmaceuticals Ltd, Allschwil, Switzerland.
Magdalena Birker-RobaczewskaIdorsia Pharmaceuticals Ltd, Allschwil, Switzerland.
Cyrille LescopIdorsia Pharmaceuticals Ltd, Allschwil, Switzerland.
Sylvie FroidevauxIdorsia Pharmaceuticals Ltd, Allschwil, Switzerland.
Nicole SchmitzIdorsia Pharmaceuticals Ltd, Allschwil, Switzerland.
Keith MorrisonIdorsia Pharmaceuticals Ltd, Allschwil, Switzerland.
Christopher KohlIdorsia Pharmaceuticals Ltd, Allschwil, Switzerland.
Markus ReyIdorsia Pharmaceuticals Ltd, Allschwil, Switzerland.
Rolf StuderIdorsia Pharmaceuticals Ltd, Allschwil, Switzerland.
Enrico VezzaliIdorsia Pharmaceuticals Ltd, Allschwil, Switzerland.
Patrick HessIdorsia Pharmaceuticals Ltd, Allschwil, Switzerland.
Martine ClozelIdorsia Pharmaceuticals Ltd, Allschwil, Switzerland.
Beat SteinerIdorsia Pharmaceuticals Ltd, Allschwil, Switzerland.
Martin H BolliIdorsia Pharmaceuticals Ltd, Allschwil, Switzerland.
Oliver NaylerIdorsia Pharmaceuticals Ltd, Allschwil, Switzerland.ORCID 0000-0001-8527-8711
Idorsia (Switzerland) · CH

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Sphingosine-1-phosphate receptor 1 (S1P

Indexed as

Administration, OralAnimalsDose-Response Relationship, DrugDrug Evaluation, PreclinicalEncephalomyelitis, Autoimmune, ExperimentalHumansHuman Umbilical Vein Endothelial CellsImmunosuppressive AgentsLymphocyte CountLymphocytesMiceOxadiazolesPyridinesRatsReceptors, LysosphingolipidSignal TransductionImmunosuppressive AgentsOxadiazolesPyridinesReceptors, Lysosphingolipidautoimmune diseasesG protein-coupled receptor signalinglipid receptorslymphocyte traffickingmultiple sclerosissphingosine-1-phosphate

Identifiers

PMID29226621
PMCPMC5723703
OpenAlexW2774703216

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.