Evidence map›Paper›PMID 29226480›Full record

ArticleClinical transplantation2018

Successful pancreas transplantation alone is associated with excellent self-identified health score and glucose control: A retrospective study from a high-volume center in the United States.

Joseph R Scalea, Lauren Pettinato, Blythe Fiscella, Amanda Bartosic, Allison Piedmonte, Jastine Paran, Niket Todi, Eric J Siskind, Stephen T Bartlett

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Clinical transplantation, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed.

  1. Trial
  2. Review
  3. Article
  4. Article
  5. Article
  6. Review
  7. Article
  8. Article
  9. Article
  10. First World Consensus Conference on pancreas transplantation: Part II - recommendations.American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons · 2021
    Article
  11. Review
  12. Article
  13. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Joseph R ScaleaDivision of Transplantation, Department of Surgery, School of Medicine, University of Maryland, Baltimore, MD, USA.ORCID 0000-0001-8278-2859
Lauren PettinatoDivision of Transplantation, Department of Surgery, School of Medicine, University of Maryland, Baltimore, MD, USA.
Blythe FiscellaDivision of Transplantation, Department of Surgery, School of Medicine, University of Maryland, Baltimore, MD, USA.
Amanda BartosicDivision of Transplantation, Department of Surgery, School of Medicine, University of Maryland, Baltimore, MD, USA.
Allison PiedmonteDivision of Transplantation, Department of Surgery, School of Medicine, University of Maryland, Baltimore, MD, USA.
Jastine ParanDivision of Transplantation, Department of Surgery, School of Medicine, University of Maryland, Baltimore, MD, USA.
Niket TodiDivision of Transplantation, Department of Surgery, School of Medicine, University of Maryland, Baltimore, MD, USA.
Eric J SiskindDivision of Transplantation, Department of Surgery, School of Medicine, University of Maryland, Baltimore, MD, USA.ORCID 0000-0001-5368-4352
Stephen T BartlettDivision of Transplantation, Department of Surgery, School of Medicine, University of Maryland, Baltimore, MD, USA.

Funding

Summer Program in Obesity, Diabetes and Nutrition Training (SPORT)T35DK095737 · NIDDK · UNIVERSITY OF MARYLAND BALTIMORE · PI STEINLE, NANETTE I · 2012 to 2021
$859k
NIDDK NIH HHS T35 DK095737
6 · The paper itself

Abstract

backgroundThe benefits of pancreas transplantation are often difficult to measure. Here, we sought to determine the difference in quality of life for diabetic patients with and without a functional pancreas transplant alone (PTA).

methodsPancreas transplant alone cases from 1993 to 2015 were considered. An IRB-approved survey inclusive of 15 questions spanning four domains was employed. Chi-square, Fisher's exact, and the T test were used where appropriate.

resultsA total of 137 PTAs were performed during the study period. Of those reached (n = 32), 94% responded to the survey. Self-reported health scores were better (2.1 vs 3.0) for those with functioning pancreata (n = 18) vs those with a non-functional pancreas (n = 14), respectively (P = .036). Those with a functional pancreas had a HgbA1c of 5.3, vs 7.7 for a non-functional pancreas (P = .016). Significant hypoglycemia was reported in two of 18 with a functional transplant vs nine of 14 patients with a failed transplant (P = .003). Daily frustration with blood sugar affecting quality of life was significantly higher for patients with non-functional pancreas grafts (P < .001).

conclusionsPancreas transplantation alone is associated with better glucose control than insulin. In addition, recipients of functional PTAs have improved quality of life and better overall health scores than those with failed grafts.

Indexed as

Graft SurvivalQuality of LifeAdultFemaleFollow-Up StudiesGlucoseHealth StatusHospitals, High-VolumeHumansHyperglycemiaHypoglycemiaMaleMiddle AgedPancreas TransplantationPrognosisYoung AdultGlucose

Identifiers

PMID29226480
PMCPMC6124664

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.