Evidence map›Paper›PMID 29226467›Full record

ReviewDevelopmental dynamics : an official publication of the American Association of Anatomists2018

Axon guidance pathways and the control of gene expression.

Samantha A Russell, Greg J Bashaw

Open access · hybridAbstract readReview
In one paragraph

Review in Developmental dynamics : an official publication of the American Association of Anatomists, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 61 papers.

0numbers the graph read from it
0cells of the map it votes in
61citing papers in PubMed
3.0field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

61 citing papers in PubMed, 105 citations in OpenAlex.

  1. Article
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  5. NADScience advances · 2025
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  6. tRFAlzheimer's research & therapy · 2025
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  7. Review
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1 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Samantha A RussellDepartment of Neuroscience, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania.
Greg J BashawDepartment of Neuroscience, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania.ORCID http://orcid.org/0000-0002-6146-0962
University of Pennsylvania · US

Funding

Molecular mechanisms of axon guidance receptor regulation and signalingR35NS097340 · NINDS · UNIVERSITY OF PENNSYLVANIA · PI BASHAW, GREG J. · 2017 to 2024
$5.8M
Graduate Training in Developmental BiologyT32HD083185 · NICHD · UNIVERSITY OF PENNSYLVANIA · PI Michael Granato, Foteini Mourkioti · 2015 to 2026
$4.0M
NICHD NIH HHS T32 HD083185NINDS NIH HHS R35 NS097340
6 · The paper itself

Abstract

Axons need to be properly guided to their targets to form synaptic connections, and this requires interactions between highly conserved extracellular and transmembrane ligands and their cell surface receptors. The majority of studies on axon guidance signaling pathways have focused on the role of these pathways in rearranging the local cytoskeleton and plasma membrane in growth cones and axons. However, a smaller body of work has demonstrated that axon guidance signaling pathways also control gene expression via local translation and transcription. Recent studies on axon guidance ligands and receptors have begun to uncover the requirements for these alternative mechanisms in processes required for neural circuit formation: axon guidance, synaptogenesis, and cell migration. Understanding the mechanisms by which axon guidance signaling regulates local translation and transcription will create a more complete picture of neural circuit formation, and they may be applied more broadly to other tissues where axon guidance ligands and receptors are required for morphogenesis. Developmental Dynamics 247:571-580, 2018. © 2017 Wiley Periodicals, Inc.

Indexed as

Gene Expression RegulationAnimalsAxon GuidanceHumansLigandsReceptors, Cell SurfaceSignal TransductionLigandsReceptors, Cell Surfaceaxon guidanceDccephrinlocal translationNetrinneural developmentplexinreceptor signalingRobosemaphorinSlittranscriptional regulationtranscription factor

Identifiers

PMID29226467
PMCPMC6167058
OpenAlexW2771832319

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.