ArticleScience advances2017
Deep tissue optical focusing and optogenetic modulation with time-reversed ultrasonically encoded light.
Article in Science advances, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
28 citing papers in PubMed.
- Largest eigenvalue statistics of wavefront shaping in complex scattering media.Nature communications · 2026Article
- Fabrication of optically transparent ultrasound transducers to integrate light and sound in multimodal biomedical systems.Nature protocols · 2026Review
- High-fidelity and high-speed wavefront shaping by leveraging complex media.Science advances · 2024Article
- All-optical phase conjugation using diffractive wavefront processing.Nature communications · 2024Article
- Large-volume focus control at 10 MHz refresh rate via fast line-scanning amplitude-encoded scattering-assisted holography.Nature communications · 2024Article
- Acoustic hologram-induced virtual in vivo enhanced waveguide (AH-VIEW).Science advances · 2024Article
- Performance enhancement in wavefront shaping of multiply scattered light: a review.Journal of biomedical optics · 2024Review
- Activation of mechanoluminescent nanotransducers by focused ultrasound enables light delivery to deep-seated tissue in vivo.Nature protocols · 2023Article
- Enhanced light focusing inside scattering media with shaped ultrasound.Scientific reports · 2023Article
- High-gain and high-speed wavefront shaping through scattering media.Nature photonics · 2023Article
- Acousto-Optics: Recent Studies and Medical Applications.Biosensors · 2023Review
- High-speed single-exposure time-reversed ultrasonically encoded optical focusing against dynamic scattering.Science advances · 2022Article
- Wavefront shaping: A versatile tool to conquer multiple scattering in multidisciplinary fields.Innovation (Cambridge (Mass.)) · 2022Review
- Wirelessly Powered 3D Printed Hierarchical Biohybrid Robots with Multiscale Mechanical Properties.Advanced functional materials · 2022Article
- Optophysiology: Illuminating cell physiology with optogenetics.Physiological reviews · 2022Review
- Ultrasound-Responsive Systems as Components for Smart Materials.Chemical reviews · 2022Review
- The Red Edge: Bilin-Binding Photoreceptors as Optogenetic Tools and Fluorescence Reporters.Chemical reviews · 2021Review
- Focusing light into scattering media with ultrasound-induced field perturbation.Light, science & applications · 2021Article
- Anti-scattering light focusing by fast wavefront shaping based on multi-pixel encoded digital-micromirror device.Light, science & applications · 2021Article
- Single-shot time-reversed optical focusing into and through scattering media.ACS photonics · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors.
Funding
Abstract
Noninvasive light focusing deep inside living biological tissue has long been a goal in biomedical optics. However, the optical scattering of biological tissue prevents conventional optical systems from tightly focusing visible light beyond several hundred micrometers. The recently developed wavefront shaping technique time-reversed ultrasonically encoded (TRUE) focusing enables noninvasive light delivery to targeted locations beyond the optical diffusion limit. However, until now, TRUE focusing has only been demonstrated inside nonliving tissue samples. We present the first example of TRUE focusing in 2-mm-thick living brain tissue and demonstrate its application for optogenetic modulation of neural activity in 800-μm-thick acute mouse brain slices at a wavelength of 532 nm. We found that TRUE focusing enabled precise control of neuron firing and increased the spatial resolution of neuronal excitation fourfold when compared to conventional lens focusing. This work is an important step in the application of TRUE focusing for practical biomedical uses.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.