ArticleScience advances2017
Single-frame 3D fluorescence microscopy with ultraminiature lensless FlatScope.
Article in Science advances, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 49 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
49 citing papers in PubMed, 201 citations in OpenAlex.
- Compact on-chip fluorescence microscope for dynamic imaging of cellular processes and biomimetic systems.JPhys photonics · 2026Article
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- DeepInMiniscope: Deep learning-powered physics-informed integrated miniscope.Science advances · 2025Article
- Maskless and on-chip LED-array microscope with spatially-varying angle calibration for centimeter-scale phase imaging.bioRxiv : the preprint server for biology · 2025Article
- Lensless camera: Unraveling the breakthroughs and prospects.Fundamental research · 2025Review
- Lensless imaging with a programmable Fresnel zone aperture.Science advances · 2025Article
- Adaptive lensless microscopic imaging with unknown phase modulation.Biomedical optics express · 2025Article
- Insertable Glucose Sensor Using a Compact and Cost-Effective Phosphorescence Lifetime Imager and Machine Learning.ACS nano · 2024Article
- EventLFM: event camera integrated Fourier light field microscopy for ultrafast 3D imaging.Light, science & applications · 2024Article
- Speckle-enabled in vivo demixing of neural activity in the mouse brain.Biomedical optics express · 2024Article
- DeepDOF-SE: affordable deep-learning microscopy platform for slide-free histology.Nature communications · 2024Article
- Mesoscopic calcium imaging in a head-unrestrained male non-human primate using a lensless microscope.Nature communications · 2024Article
- Three-dimensional topology-based analysis segments volumetric and spatiotemporal fluorescence microscopy.Biological imaging · 2024Article
- Real-time, deep-learning aided lensless microscope.Biomedical optics express · 2023Article
- An optical design enabling lightweight and large field-of-view head-mounted microscopes.Nature methods · 2023Article
- Mesoscale volumetric light-field (MesoLF) imaging of neuroactivity across cortical areas at 18 Hz.Nature methods · 2023Article
- Learned lensless 3D camera.Optics express · 2022Article
- In vivo lensless microscopy via a phase mask generating diffraction patterns with high-contrast contours.Nature biomedical engineering · 2022Article
- FlatNet: Towards Photorealistic Scene Reconstruction From Lensless Measurements.IEEE transactions on pattern analysis and machine intelligence · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Modern biology increasingly relies on fluorescence microscopy, which is driving demand for smaller, lighter, and cheaper microscopes. However, traditional microscope architectures suffer from a fundamental trade-off: As lenses become smaller, they must either collect less light or image a smaller field of view. To break this fundamental trade-off between device size and performance, we present a new concept for three-dimensional (3D) fluorescence imaging that replaces lenses with an optimized amplitude mask placed a few hundred micrometers above the sensor and an efficient algorithm that can convert a single frame of captured sensor data into high-resolution 3D images. The result is FlatScope: perhaps the world's tiniest and lightest microscope. FlatScope is a lensless microscope that is scarcely larger than an image sensor (roughly 0.2 g in weight and less than 1 mm thick) and yet able to produce micrometer-resolution, high-frame rate, 3D fluorescence movies covering a total volume of several cubic millimeters. The ability of FlatScope to reconstruct full 3D images from a single frame of captured sensor data allows us to image 3D volumes roughly 40,000 times faster than a laser scanning confocal microscope while providing comparable resolution. We envision that this new flat fluorescence microscopy paradigm will lead to implantable endoscopes that minimize tissue damage, arrays of imagers that cover large areas, and bendable, flexible microscopes that conform to complex topographies.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.