Evidence map›Paper›PMID 29226239›Full record

ArticleACS biomaterials science & engineering2017

Deconstructing the Tissue Engineered Vascular Graft: Evaluating Scaffold Pre-Wetting, Conditioned Media Incubation, and Determining the Optimal Mononuclear Cell Source.

Cameron Best, Shuhei Tara, Matthew Wiet, James Reinhardt, Victoria Pepper, Matthew Ball, Tai Yi, Toshiharu Shinoka, Christopher Breuer

Abstract read
In one paragraph

Article in ACS biomaterials science & engineering, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed.

  1. Article
  2. Hemodynamics and Wall Mechanics of Vascular Graft Failure.Arteriosclerosis, thrombosis, and vascular biology · 2024
    Review
  3. Review
  4. Review
  5. Review
  6. Zoledronate alters natural progression of tissue-engineered vascular grafts.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2021
    Article
  7. Article
  8. Article
  9. Review
  10. Article
  11. Article
  12. Article
  13. Review
  14. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Cameron BestTissue Engineering and Surgical Research, The Research Institute at Nationwide Children's Hospital, Columbus, Ohio, United States.
Shuhei TaraTissue Engineering and Surgical Research, The Research Institute at Nationwide Children's Hospital, Columbus, Ohio, United States.
Matthew WietTissue Engineering and Surgical Research, The Research Institute at Nationwide Children's Hospital, Columbus, Ohio, United States.
James ReinhardtTissue Engineering and Surgical Research, The Research Institute at Nationwide Children's Hospital, Columbus, Ohio, United States.
Victoria PepperTissue Engineering and Surgical Research, The Research Institute at Nationwide Children's Hospital, Columbus, Ohio, United States.
Matthew BallDepartment of Pathology, The Ohio State University College of Medicine, Columbus, Ohio, United States.
Tai YiTissue Engineering and Surgical Research, The Research Institute at Nationwide Children's Hospital, Columbus, Ohio, United States.
Toshiharu ShinokaTissue Engineering and Surgical Research, The Research Institute at Nationwide Children's Hospital, Columbus, Ohio, United States.
Christopher BreuerTissue Engineering and Surgical Research, The Research Institute at Nationwide Children's Hospital, Columbus, Ohio, United States.

Funding

Mechanisms of Vascular Neotissue Formation In Tissue Engineered Vascular GraftsR01HL098228 · NHLBI · YALE UNIVERSITY · PI BREUER, CHRISTOPHER KANE · 2010 to 2018
$3.6M
Development of an Improved Vascular Graft for Use in Congenital Heart SurgeryR01HL128847 · NHLBI · RESEARCH INST NATIONWIDE CHILDREN'S HOSP · PI BREUER, CHRISTOPHER KANE · 2016 to 2019
$2.8M
Training in Congenital and Acquired Heart DiseaseT32HL098039 · NHLBI · RESEARCH INST NATIONWIDE CHILDREN'S HOSP · PI GARG, VIDU, MOHLER, PETER J. · 2009 to 2019
$2.5M
NHLBI NIH HHS R01 HL098228NHLBI NIH HHS R01 HL128847NHLBI NIH HHS T32 HL098039
6 · The paper itself

Abstract

Stenosis limits widespread use of tissue-engineered vascular grafts (TEVGs), and bone marrow mononuclear cell (BM-MNC) seeding attenuates this complication. Yet seeding is a multistep process, and the singular effects of each component are unknown. We investigated which components of the clinical seeding protocol confer graft patency and sought to identify the optimal MNC source. Scaffolds composed of polyglycolic acid and

Indexed as

biodegradable scaffoldbone marrowIL-1βIL-6mononuclear cellmouse modelperipheral bloodplateletseedingstenosistissue engineered vascular graftTNFα

Identifiers

PMID29226239
PMCPMC5720152

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.