ArticleACS macro letters2017
Ultra-Low Dispersity Poly(vinyl alcohol) Reveals Significant Dispersity Effects on Ice Recrystallization Inhibition Activity.
Article in ACS macro letters, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
11 citing papers in PubMed.
- Monodisperse oligo(ε-caprolactones) with terpenes and alkyl end-groups: synthesis, isolation, characterization, and antibacterial activity.RSC advances · 2025Article
- Chromatographic Separation: A Versatile Strategy to Prepare Discrete and Well-Defined Polymer Libraries.Accounts of chemical research · 2024Article
- Enhanced Cellular Cryopreservation by Biopolymer-Associated Suppression of RhoA/ROCK Signaling Pathway.Materials (Basel, Switzerland) · 2021Article
- Article
- The atomistic details of the ice recrystallisation inhibition activity of PVA.Nature communications · 2021Article
- Ice recrystallisation inhibiting polymers prevent irreversible protein aggregation during solvent-free cryopreservation as additives and as covalent polymer-protein conjugates.European polymer journal · 2020Article
- Article
- Enhancement of Macromolecular Ice Recrystallization Inhibition Activity by Exploiting Depletion Forces.ACS macro letters · 2019Article
- Mimicking the Ice Recrystallization Activity of Biological Antifreezes. When is a New Polymer "Active"?Macromolecular bioscience · 2019Review
- Multivalent Presentation of Ice Recrystallization Inhibiting Polymers on Nanoparticles Retains Activity.Langmuir : the ACS journal of surfaces and colloids · 2019Article
- Ice Recrystallization Inhibiting Polymers Enable Glycerol-Free Cryopreservation of Microorganisms.Biomacromolecules · 2018Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
Abstract
Polymer mimics of antifreeze proteins are emerging as an exciting class of macromolecular cryoprotectants for the storage of donor cells and tissue. Poly(vinyl alcohol), PVA, is the most potent polymeric ice growth inhibitor known, but its mode of action and the impact of valency (DP) are not fully understood. Herein, tandem RAFT polymerization and column chromatography are used to isolate oligomers with dispersities <1.01 to enable the effect of molecular weight distribution, as well as length, to be probed. It is found that polymers with equal number average molecular weight, but lower dispersity, have significantly less activity, which can lead to false positives when identifying structure-property relationships. The minimum chain length for PVA's unique activity, compared to other non-active poly-ols was identified. These results will guide the design of more active inhibitors, better cryopreservatives and a deeper understanding of synthetic and biological antifreeze macromolecules.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.