ArticleJournal of nutrition and metabolism2017
Metabolic Differences between Dogs of Different Body Sizes.
Article in Journal of nutrition and metabolism, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
30 citing papers in PubMed, 45 citations in OpenAlex.
- Biomechanical evaluation of structural integrity after tibial plateau leveling osteotomy in dogs using finite element analysis.Scientific reports · 2026Article
- Evidence of emerging transcriptome mediators of Alzheimer's disease in canine cognitive dysfunction.Brain pathology (Zurich, Switzerland) · 2026Article
- Successful treatment of ibuprofen intoxication using hemoperfusion with porous polymeric adsorbents in a toy poodle.The Journal of veterinary medical science · 2026Article
- Dogs and humans share biomarkers of mortality.The journals of gerontology. Series A, Biological sciences and medical sciences · 2026Article
- Effects of Dietary Supplementation with Whole Lamb Omasum on Gut Health and Metabolism in Shiba Inu Dogs.Veterinary sciences · 2026Article
- Unveiling the significance of dog domestication in cognitive dysfunction: Are wolves protected?Open veterinary journal · 2025Article
- The gut microbiota of Labrador retriever puppies: a longitudinal cohort study.Animal microbiome · 2025Article
- Effects of cRG-I Prebiotic Treatment on Gut Microbiota Composition and Metabolic Activity in Dogs In Vitro.Microorganisms · 2025Article
- Involvement of TGF-β, mTOR, and inflammatory mediators in aging alterations during myxomatous mitral valve disease in a canine model.GeroScience · 2025Review
- Rationale and design of the Dog Aging Project precision cohort: a multi-omic resource for longitudinal research in geroscience.GeroScience · 2025Article
- Understanding the diversity and roles of the canine gut microbiome.Journal of animal science and biotechnology · 2025Review
- A biological age based on common clinical markers predicts health trajectory and mortality risk in dogs.GeroScience · 2025Article
- Purebred dogs show higher levels of genomic damage compared to mixed breed dogs.Mammalian genome : official journal of the International Mammalian Genome Society · 2024Article
- A revisiting of "the hallmarks of aging" in domestic dogs: current status of the literature.GeroScience · 2024Review
- Characteristics of Nutrition and Metabolism in Dogs and Cats.Advances in experimental medicine and biology · 2024Article
- Comparison of muscle metabolomics between two Chinese horse breeds.Frontiers in veterinary science · 2023Article
- Age, breed, sex and diet influence serum metabolite profiles of 2000 pet dogs.Royal Society open science · 2022Article
- Fecal microbiota and inflammatory and antioxidant status of obese and lean dogs, and the effect of caloric restriction.Frontiers in microbiology · 2022Article
- Gut microbiota development in the growing dog: A dynamic process influenced by maternal, environmental and host factors.Frontiers in veterinary science · 2022Review
- Effect of 6-Month Feeding with a Diet Enriched in EPA + DHA from Fish Meat on the Blood Metabolomic Profile of Dogs with Myxomatous Mitral Valve Disease.Animals : an open access journal from MDPI · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors at 4 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionThe domesticated dog,
objectivesThis study aims to identify metabolic, clinical, and microbiota differences between small and larger dogs.
methodsGas chromatography/mass spectrometry, liquid chromatography/tandem mass spectrometry, clinical chemistry analysis, dual-energy X-ray absorptiometry, and 16S pyrosequencing were used to characterize blood metabolic, clinical, and fecal microbiome systems, respectively. Eighty-three canines from seven different breeds, fed the same kibble diet for 5 weeks, were used in the study.
results449 metabolites, 16 clinical parameters, and 6 bacteria (at the genus level) were significantly different between small and larger dogs. Hierarchical clustering of the metabolites yielded 8 modules associated with small dog size.
conclusionSmall dogs had a lower antioxidant status and differences in circulating amino acids. Some of the amino acid differences could be attributed to differences in microflora. Additionally, analysis of small dog metabolites and clinical parameters reflected a network which strongly associates with kidney function.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.