Evidence map›Paper›PMID 29225919›Full record

ArticleRMD open2017

Multiple common and rare variants of

Toshihide Higashino, Tappei Takada, Hirofumi Nakaoka, Yu Toyoda, Blanka Stiburkova, Hiroshi Miyata, Yuki Ikebuchi, Hiroshi Nakashima, Seiko Shimizu, Makoto Kawaguchi and 18 more

Open access · goldAbstract read
In one paragraph

Article in RMD open, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
37citing papers in PubMed, 2 pooled it
5.7field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

37 citing papers in PubMed, 2 syntheses or guidelines pooled it, 69 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Trial
  4. Review
  5. Review
  6. Review
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  17. Cannabis Pharmacogenomics: A Path to Personalized Medicine.Current issues in molecular biology · 2023
    Review
  18. The frequency of rs2231142 inPharmacogenomics · 2023
    Review
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

28 authors at 8 institutions in 3 countries.

Toshihide HigashinoDepartment of Integrative Physiology and Bio-Nano Medicine, National Defense Medical College, Tokorozawa, Japan.
Tappei TakadaDepartment of Pharmacy, The University of Tokyo Hospital, Faculty of Medicine, The University of Tokyo, Tokyo, Japan.
Hirofumi NakaokaDivision of Human Genetics, Department of Integrated Genetics, National Institute of Genetics, Mishima, Japan.
Yu ToyodaDepartment of Pharmacy, The University of Tokyo Hospital, Faculty of Medicine, The University of Tokyo, Tokyo, Japan.
Blanka StiburkovaFirst Faculty of Medicine, Charles University and General University Hospital in Prague, Institute of Inherited Metabolic Disorders, Prague, Czech Republic.
Hiroshi MiyataDepartment of Pharmacy, The University of Tokyo Hospital, Faculty of Medicine, The University of Tokyo, Tokyo, Japan.
Yuki IkebuchiDepartment of Pharmacy, The University of Tokyo Hospital, Faculty of Medicine, The University of Tokyo, Tokyo, Japan.
Hiroshi NakashimaDepartment of Preventive Medicine and Public Health, National Defense Medical College, Tokorozawa, Japan.
Seiko ShimizuDepartment of Integrative Physiology and Bio-Nano Medicine, National Defense Medical College, Tokorozawa, Japan.
Makoto KawaguchiDepartment of Integrative Physiology and Bio-Nano Medicine, National Defense Medical College, Tokorozawa, Japan.
Masayuki SakiyamaDepartment of Integrative Physiology and Bio-Nano Medicine, National Defense Medical College, Tokorozawa, Japan.
Akiyoshi NakayamaDepartment of Integrative Physiology and Bio-Nano Medicine, National Defense Medical College, Tokorozawa, Japan.
Airi AkashiDepartment of Integrative Physiology and Bio-Nano Medicine, National Defense Medical College, Tokorozawa, Japan.
Yuki TanahashiDepartment of Integrative Physiology and Bio-Nano Medicine, National Defense Medical College, Tokorozawa, Japan.
Yusuke KawamuraDepartment of Integrative Physiology and Bio-Nano Medicine, National Defense Medical College, Tokorozawa, Japan.
Takahiro NakamuraLaboratory for Mathematics, National Defense Medical College, Tokorozawa, Japan.
Kenji WakaiDepartment of Preventive Medicine, Nagoya University Graduate School of Medicine, Nagoya, Japan.
Rieko OkadaDepartment of Preventive Medicine, Nagoya University Graduate School of Medicine, Nagoya, Japan.
Ken YamamotoDepartment of Medical Chemistry, Kurume University School of Medicine, Kurume, Japan.
Kazuyoshi HosomichiDivision of Human Genetics, Department of Integrated Genetics, National Institute of Genetics, Mishima, Japan.
Tatsuo HosoyaDivision of Kidney and Hypertension, Department of Internal Medicine, Jikei University School of Medicine, Tokyo, Japan.
Kimiyoshi IchidaDivision of Kidney and Hypertension, Department of Internal Medicine, Jikei University School of Medicine, Tokyo, Japan.
Hiroshi OoyamaRyougoku East Gate Clinic, Tokyo, Japan.
Hiroshi SuzukiDepartment of Pharmacy, The University of Tokyo Hospital, Faculty of Medicine, The University of Tokyo, Tokyo, Japan.
Ituro InoueDivision of Human Genetics, Department of Integrated Genetics, National Institute of Genetics, Mishima, Japan.
Tony R MerrimanDepartment of Biochemistry, University of Otago, Dunedin, New Zealand.
Nariyoshi ShinomiyaDepartment of Integrative Physiology and Bio-Nano Medicine, National Defense Medical College, Tokorozawa, Japan.
Hirotaka MatsuoDepartment of Integrative Physiology and Bio-Nano Medicine, National Defense Medical College, Tokorozawa, Japan.
National Defense Medical College · JPUniversity of Tokyo Hospital · JPNational Institute of Genetics · JPJikei University School of Medicine · JPNagoya University · JPGeneral University Hospital in Prague · CZKurume University Medical Center · JPUniversity of Otago · NZ

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivePrevious studies have suggested an association between gout susceptibility and common dysfunctional variants in ATP-binding cassette transporter subfamily G member 2/breast cancer resistance protein (

methodsWe sequenced the exons of

resultsWe identified 3 common and 19 rare non-synonymous variants of

conclusionsThis study revealed that multiple common and rare variants of

Indexed as

arthritisepidemiologygene polymorphismgout

Identifiers

PMID29225919
PMCPMC5706492
OpenAlexW2753140606

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.