Evidence map›Paper›PMID 29225896›Full record

ArticleBMJ open diabetes research & care2017

Incidence of diabetes mellitus and factors associated with its development in HIV-positive patients over the age of 50.

Faizal Samad, Marianne Harris, Cathy M Puskas, Monica Ye, Jason Chia, Sarah Chacko, Gregory P Bondy, Viviane D Lima, Julio Sg Montaner, Silvia A Guillemi

Abstract read
In one paragraph

Article in BMJ open diabetes research & care, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
37citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

37 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
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  7. Observational
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  9. Article
  10. Cardiometabolic health in people with HIV: expert consensus review.The Journal of antimicrobial chemotherapy · 2024
    Review
  11. Interventions for Type 2 Diabetes reduction among older people living with HIV in Harare.South African family practice : official journal of the South African Academy of Family Practice/Primary Care · 2024
    Review
  12. Article
  13. Article
  14. Risks of Type 2 diabetes among older people living with HIV: A scoping review.South African family practice : official journal of the South African Academy of Family Practice/Primary Care · 2023
    Article
  15. Article
  16. Article
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  19. Associations of HIV and Depression with Incident Diabetes Mellitus: Veterans Aging Cohort Study.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2022
    Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Faizal SamadAIDS Research Program, St. Paul's Hospital, Vancouver, British Columbia, Canada.
Marianne HarrisJohn Ruedy Immunodeficiency Clinic, British Columbia Centre for Excellence in HIV/AIDS, Vancouver, British Columbia, Canada.
Cathy M PuskasClinical Education and Training Program, British Columbia Centre for Excellence in HIV/AIDS, Vancouver, British Columbia, Canada.
Monica YeEpidemiology and Population Health, British Columbia Centre for Excellence in HIV/AIDS, Vancouver, British Columbia, Canada.
Jason ChiaEpidemiology and Population Health, British Columbia Centre for Excellence in HIV/AIDS, Vancouver, British Columbia, Canada.
Sarah ChackoNorwich Medical School, University of East Anglia, Norwich, UK.
Gregory P BondyDepartments of Medicine and Pathology, Faculty of Medicine, University of British Columbia, Vancouver, British Columbia, Canada.
Viviane D LimaEpidemiology and Population Health, British Columbia Centre for Excellence in HIV/AIDS, Vancouver, British Columbia, Canada.
Julio Sg MontanerJohn Ruedy Immunodeficiency Clinic, British Columbia Centre for Excellence in HIV/AIDS, Vancouver, British Columbia, Canada.
Silvia A GuillemiDepartment of Family Practice, Faculty of Medicine, University of British Columbia, Vancouver, British Columbia, Canada.

Funding

Seek and Treat for Optimal Prevention of HIV & AIDS (STOP HIV/AIDS) in BCR01DA036307 · NIDA · UNIVERSITY OF BRITISH COLUMBIA · PI MONTANER, JULIO SERGIO GONZALEZ · 2013 to 2017
$3.0M
NIDA NIH HHS R01 DA036307
6 · The paper itself

Abstract

objectiveWe sought to determine the incidence and factors associated with development of diabetes mellitus (DM) in older HIV-infected individuals. RESEARCH DESIGN AND

methodsWe analyzed data from people living with HIV (PLWH) ≥50 years of age enrolled in a large urban HIV outpatient clinic in Vancouver, British Columbia. Patients were categorized as having DM if they had random blood sugar ≥11.1 mmol/L, fasting blood sugar ≥7 mmol/L, HbA1C ≥6.5%, antidiabetic medication use during the follow-up period, or medical chart review confirming diagnosis of DM. We estimated the probability of developing DM, adjusting for demographic and clinical factors, using a logistic regression model.

resultsAmong 1065 PLWH followed for a median of 13 years (25th and 75th percentile (Q1-Q3): 9-18), the incidence of DM was 1.61/100 person-years follow-up. In the analysis of factors associated with new-onset DM (n=703), 88% were male, 38% had a history of injection drug use, 43% were hepatitis C coinfected, and median body mass index was 24 kg/m

conclusionsAmong PLWH aged ≥50 years, the incidence of DM was 1.39 times higher than men in the general Canadian population of similar age. ART initiated in the early years of the epidemic and exposure to older ART appeared to be the main drivers of the development of DM.

Indexed as

adult diabetesaginghivincidence

Identifiers

PMID29225896
PMCPMC5717418

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.