ArticleClinical kidney journal2017
Perioperative Plasma-Lyte use reduces the incidence of renal replacement therapy and hyperkalaemia following renal transplantation when compared with 0.9% saline: a retrospective cohort study.
Article in Clinical kidney journal, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 47 citations in OpenAlex.
- A pragmatic, open-label, randomized controlled trial of Plasma-Lyte-148 versus standard intravenous fluids in children receiving kidney transplants (PLUTO).Kidney international · 2024Trial
- Perioperative fluid management in kidney transplantation: What's new and future directives?World journal of nephrology · 2026Review
- Intraoperative hydroxyethyl starch 130/0.4 infusion and graft function following donation-after-cardiac-death kidney transplantation.iScience · 2026Article
- Fluid Selection in Renal Transplant Patients: Considerations for Hyperkalemia Management.Turkish journal of anaesthesiology and reanimation · 2025Article
- Stewart's theory and acid-base changes induced by crystalloid infusion in humans: a randomized physiological trial.Annals of intensive care · 2025Article
- Perioperative management of kidney transplantation in China: A national survey in 2021.PloS one · 2024Article
- Ideal burn resuscitation: a step toward resolving the dilemma in acute flame burn management.International journal of burns and trauma · 2024Article
- Perioperative anaesthesia management of renal transplant recipients - A national cross-sectional survey.Indian journal of anaesthesia · 2023Article
- Potassium level changes in chronic kidney disease patients following balanced crystalloid administration in the emergency department.Medicine · 2023Article
- Electrolyte derangements in critically ill children receiving balanced versus unbalanced crystalloid fluid resuscitation.BMC nephrology · 2022Observational
- Baseline Characteristics and Representativeness of Participants in the BEST-Fluids Trial: A Randomized Trial of Balanced Crystalloid Solution Versus Saline in Deceased Donor Kidney Transplantation.Transplantation direct · 2022Article
- Use of normal saline and incidence of dyselectrolytaemia in children following kidney transplantation.Pediatric nephrology (Berlin, Germany) · 2022Observational
- Effects of the Type of Intraoperative Fluid in Living Donor Kidney Transplantation: A Single-Center Retrospective Cohort Study.Yonsei medical journal · 2022Article
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- Crystalloid and Colloid Compositions and Their Impact.Frontiers in veterinary science · 2021Review
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- Hyperkalemia: pathophysiology, risk factors and consequences.Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association · 2019Review
- Perioperative management of adult cadaveric and live donor renal transplantation in the UK: a survey of national practice.Clinical kidney journal · 2019Article
- Ab-normal saline in abnormal kidney function: risks and alternatives.Pediatric nephrology (Berlin, Germany) · 2019Review
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundKidney transplant recipients often receive large volumes of intravenous fluid replacement in the peri-operative period. Administration of 0.9% saline has previously been associated with acidosis, hyperkalaemia and acute kidney injury. The perioperative use of physiologically balanced replacement fluids may reduce the incidence of post-operative renal replacement therapy and hyperkalaemia.
methodsA retrospective review of consecutive renal transplants before and after a change in perioperative fluid prescription from 0.9% saline to Plasma-Lyte 148.
resultsA total of 97 patients were included in the study, 59 receiving exclusively 0.9% saline and 38 receiving exclusively Plasma-Lyte. Patients in the Plasma-Lyte group were less likely to require emergency postoperative dialysis than those receiving 0.9% saline [odds ratio (OR) 0.15 (95% confidence interval 0.03-0.48), P = 0.004], and these patients had more favourable biochemical parameters with less hyperkalaemia, less acidosis and better diuresis. Patients in the Plasma-Lyte group also had a shorter length of hospital stay (7 days versus 11 days; P < 0.0001) and better graft function at 3 months postoperatively (estimated glomerular filtration rate 51 versus 44 mL/min/1.73 m
conclusionsPlasma-Lyte in the perioperative period is safe in renal transplantation and is associated with a favourable biochemical profile, including a reduced incidence of hyperkalaemia, better diuresis and less frequent use of renal replacement therapy early after surgery. In patients receiving Plasma-Lyte, graft function was better at 3 months, but this difference did not persist up to 1 year after transplantation.
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