Evidence map›Paper›PMID 29225692›Full record

ReviewEcancermedicalscience2017

Recent advances in radiation oncology.

Cristina Garibaldi, Barbara Alicja Jereczek-Fossa, Giulia Marvaso, Samantha Dicuonzo, Damaris Patricia Rojas, Federica Cattani, Anna Starzyńska, Delia Ciardo, Alessia Surgo, Maria Cristina Leonardi and 1 more

Abstract readReview
In one paragraph

Review in Ecancermedicalscience, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 57 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
57citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

57 citing papers in PubMed, 2 syntheses or guidelines pooled it.

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  17. Successful implementation of online educational lectures of the German Society for Radiation Oncology (DEGRO).Strahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al] · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Cristina GaribaldiUnit of Medical Physics, European Institute of Oncology, 20141 Milan, Italy.
Barbara Alicja Jereczek-FossaDepartment of Radiation Oncology, European Institute of Oncology, 20141 Milan, Italy.
Giulia MarvasoDepartment of Radiation Oncology, European Institute of Oncology, 20141 Milan, Italy.
Samantha DicuonzoDepartment of Radiation Oncology, European Institute of Oncology, 20141 Milan, Italy.
Damaris Patricia RojasDepartment of Radiation Oncology, European Institute of Oncology, 20141 Milan, Italy.
Federica CattaniUnit of Medical Physics, European Institute of Oncology, 20141 Milan, Italy.
Anna StarzyńskaDepartment of Oral Surgery, Medical University of Gdańsk, 80-211 Gdańsk, Poland.
Delia CiardoDepartment of Radiation Oncology, European Institute of Oncology, 20141 Milan, Italy.
Alessia SurgoDepartment of Radiation Oncology, European Institute of Oncology, 20141 Milan, Italy.
Maria Cristina LeonardiDepartment of Radiation Oncology, European Institute of Oncology, 20141 Milan, Italy.
Rosalinda RicottiDepartment of Radiation Oncology, European Institute of Oncology, 20141 Milan, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Radiotherapy (RT) is very much a technology-driven treatment modality in the management of cancer. RT techniques have changed significantly over the past few decades, thanks to improvements in engineering and computing. We aim to highlight the recent developments in radiation oncology, focusing on the technological and biological advances. We will present state-of-the-art treatment techniques, employing photon beams, such as intensity-modulated RT, volumetric-modulated arc therapy, stereotactic body RT and adaptive RT, which make possible a highly tailored dose distribution with maximum normal tissue sparing. We will analyse all the steps involved in the treatment: imaging, delineation of the tumour and organs at risk, treatment planning and finally image-guidance for accurate tumour localisation before and during treatment delivery. Particular attention will be given to the crucial role that imaging plays throughout the entire process. In the case of adaptive RT, the precise identification of target volumes as well as the monitoring of tumour response/modification during the course of treatment is mainly based on multimodality imaging that integrates morphological, functional and metabolic information. Moreover, real-time imaging of the tumour is essential in breathing adaptive techniques to compensate for tumour motion due to respiration. Brief reference will be made to the recent spread of particle beam therapy, in particular to the use of protons, but also to the yet limited experience of using heavy particles such as carbon ions. Finally, we will analyse the latest biological advances in tumour targeting. Indeed, the effectiveness of RT has been improved not only by technological developments but also through the integration of radiobiological knowledge to produce more efficient and personalised treatment strategies.

Indexed as

adaptive radiotherapyimage guided radiotherapyintensity-modulated radiotherapyradiogenomicsstereotactic body radiotherapy

Identifiers

PMID29225692
PMCPMC5718253

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.