ReviewNeuropsychiatric disease and treatment2017
Korsakoff's syndrome: a critical review.
Review in Neuropsychiatric disease and treatment, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 120 papers, 4 of them syntheses that pooled it.
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Who cites it
120 citing papers in PubMed, 4 syntheses or guidelines pooled it, 259 citations in OpenAlex.
- Social cognition in Korsakoff's syndrome: A meta-analysis.Addiction (Abingdon, England) · 2026Pooled it
- Wernicke encephalopathy in non-alcoholic patients following gastrointestinal procedures: a systematic review.Frontiers in surgery · 2026Pooled it
- Assessment of agitation and aggression in inpatients with alcohol use disorder: A systematic review of informant-based scales.Alcohol, clinical & experimental research · 2025Pooled it
- Substance abuse and susceptibility to false memory formation: a systematic review and meta-analysis.Frontiers in psychology · 2023Pooled it
- The effects of strategy training on spatial memory in diencephalic amnesia: a randomized controlled study.Cognitive processing · 2020Trial
- [Diagnostic challenges of Wernicke-Korsakoff syndrome: A case report].Neuropsychiatrie : Klinik, Diagnostik, Therapie und Rehabilitation : Organ der Gesellschaft Osterreichischer Nervenarzte und Psychiater · 2026Article
- Non-Alcoholic Wernicke-Korsakoff Syndrome After a Whipple Procedure: Delayed Recognition, Neuropsychological Findings, and Rehabilitation Follow-Up: A Case Report.Reports (MDPI) · 2026Article
- Believe Your Patient Who Denies Alcohol Dependence/Celiac Disease as a Cause of Wernicke Encephalopathy.ACG case reports journal · 2026Article
- Subjective experience of 'Stream of Consciousness Impairment' in three patients with severe amnesia.Neuroscience of consciousness · 2026Article
- Effects of Introducing the Bbrainklok as a Digital External Memory Aid on Prospective Memory, Apathy and Autonomy in Individuals with Korsakoff's Syndrome.Neuropsychiatric disease and treatment · 2026Article
- Clinical and Etiopathological Perspective of Vitamin B1 Hypersensitivity and an Example of a Desensitization Protocol.Life (Basel, Switzerland) · 2025Review
- Scoping review of micronutrient imbalances, clinical manifestations, and interventions.World journal of methodology · 2025Review
- Persistent Refractory Headaches Following Non-alcoholic Wernicke's Encephalopathy in a Teenager.Cureus · 2025Article
- Sparse memory ensembles set brain-wide network states to sustain learned associations.iScience · 2025Article
- Article
- Theory of mind deficits in Korsakoff's syndrome and alcohol use disorder: Similar deficits but different underlying cognitive processes.Alcohol, clinical & experimental research · 2025Article
- Fortifying alcoholic beverages with thiamine: Lessons from history and future opportunities.Drug and alcohol dependence reports · 2025Article
- Thiamine Deficiency and Brain Injury: Neuroanatomical Changes in the Wernicke-Korsakoff Syndrome.Cureus · 2025Review
- Thiamine Deficiency and Neuroinflammation Are Important Contributors to Alcohol Use Disorder.Pathophysiology : the official journal of the International Society for Pathophysiology · 2025Review
- Swept-Source Optical Coherence Tomography in the Diagnosis and Monitoring of Optic Nerve Neuropathy in Patients with Wernicke's Encephalopathy Due to Hyperemesis Gravidarum.Journal of clinical medicine · 2025Review
60 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
3 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In this review, we present a survey on Korsakoff's syndrome (KS), a residual syndrome in patients who suffered from a Wernicke encephalopathy (WE) that is predominantly characterized by global amnesia, and in more severe cases also by cognitive and behavioral dysfunction. We describe the history of KS and its definition, its epidemiology, and the lack of consensus criteria for its diagnosis. The cognitive and behavioral symptoms of KS, which include anterograde and retrograde amnesia, executive dysfunction, confabulation, apathy, as well as affective and social-cognitive impairments, are discussed. Moreover, recent insights into the underlying neurocognitive mechanisms of these symptoms are presented. In addition, the evidence so far on the etiology of KS is examined, highlighting the role of thiamine and alcohol and discussing the continuity hypothesis. Furthermore, the neuropathology of KS is reviewed, focusing on abnormalities in the diencephalon, including the mammillary bodies and thalamic nuclei. Pharmacological treatment options and nonpharmacological interventions, such as those based on cognitive rehabilitation, are discussed. Our review shows that thiamine deficiency (TD) is a crucial factor in the etiology of KS. Although alcohol abuse is by far the most important context in which TD occurs, there is no convincing evidence for an essential contribution of ethanol neurotoxicity (EN) to the development of WE or to the progression of WE to KS. Future research on the postmortem histopathological analysis of brain tissues of KS patients is crucial for the advancement of our knowledge of KS, especially for associating its symptoms with lesions in various thalamic nuclei. A necessary requirement for the advancement of studies on KS is the broad acceptance of a comprehensive definition and definite diagnostic criteria. Therefore, in this review, we propose such a definition of KS and draft outlines for prospective diagnostic criteria.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.