Evidence map›Paper›PMID 29225410›Full record

ArticleJournal of Raman spectroscopy : JRS2017

Conformational Differentiation of α-Cyanohydroxycinnamic Acid Isomers: A Raman Spectroscopic Study.

Jayson Vedad, Maciej E Domaradzki, Elmer-Rico E Mojica, Emmanuel J Chang, Adam A Profit, Ruel Z B Desamero

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of Raman spectroscopy : JRS, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Jayson VedadDepartment of Chemistry, York College and The Institute for Macromolecular Assemblies, Jamaica, NY, 11451 and Ph.D Programs in Chemistry and Biochemistry, The Graduate Center of the City University of New York, New York, New York, 10016 (United States).
Maciej E DomaradzkiDepartment of Chemistry, York College and The Institute for Macromolecular Assemblies, Jamaica, NY, 11451 and Ph.D Programs in Chemistry and Biochemistry, The Graduate Center of the City University of New York, New York, New York, 10016 (United States).
Elmer-Rico E MojicaDepartment of Chemistry, York College and The Institute for Macromolecular Assemblies, Jamaica, NY, 11451 and Ph.D Programs in Chemistry and Biochemistry, The Graduate Center of the City University of New York, New York, New York, 10016 (United States).
Emmanuel J ChangDepartment of Chemistry, York College and The Institute for Macromolecular Assemblies, Jamaica, NY, 11451 and Ph.D Programs in Chemistry and Biochemistry, The Graduate Center of the City University of New York, New York, New York, 10016 (United States).
Adam A ProfitDepartment of Chemistry, York College and The Institute for Macromolecular Assemblies, Jamaica, NY, 11451 and Ph.D Programs in Chemistry and Biochemistry, The Graduate Center of the City University of New York, New York, New York, 10016 (United States).
Ruel Z B DesameroDepartment of Chemistry, York College and The Institute for Macromolecular Assemblies, Jamaica, NY, 11451 and Ph.D Programs in Chemistry and Biochemistry, The Graduate Center of the City University of New York, New York, New York, 10016 (United States).

Funding

Dihydropteridine Reductase: Mechanism of Enzyme ActionSC3GM089624 · NIGMS · YORK COLLEGE · PI DESAMERO, RUEL Z B · 2010 to 2013
$461k
NIGMS NIH HHS SC3 GM089624
6 · The paper itself

Abstract

Two α-cyanohydroxycinnamic acid positional isomers, α-cyano-4-hydroxycinnamic acid (CHCA4) and α-cyano-3-hydroxycinnamic acid (CHCA3), were characterized using Raman spectroscopy. We analyzed the implications of the collected Raman spectral shifts, and verified them through other spectroscopic techniques, to arrive at plausible three dimensional structures of CHCA3 and CHCA4. The positions of these groups were mapped by systematically analyzing the orientation and type of interactions functional groups make in each CHCA isomer. We determined whether or not the carboxylic moieties are forming dimeric links and ascertained the existence of ring-ring π-stacking interactions. We also assessed the nature of the hydrogen bonding between -CN and -OH groups. The results were then taken together to model plausible three dimensional structures for each compound. The data revealed a structure for CHCA4 that matches the published x-ray crystallographic structure. We then applied the same spectral analysis to CHCA3 to reveal its plausible three dimensional structure. The structural details revealed may account for the functional properties of the two α-cyanohydroxycinnamic acid positional isomers.

Identifiers

PMID29225410
PMCPMC5720387

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