ReviewInfection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases2018
Microbial diversity within the airway microbiome in chronic pediatric lung diseases.
Review in Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04765033 (Efficacy of Nebulised 5% Hypertonic Saline in Children With Chronic Suppurative Lung Disease), which is not on this map. Cited by 20 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Efficacy of Nebulised 5% Hypertonic Saline in Children With Chronic Suppurative Lung Disease
Who cites it
20 citing papers in PubMed, 31 citations in OpenAlex.
- Clinical and Immunological Perspectives on the Nasal Microbiome's Role in Olfactory Function and Dysfunction.Microorganisms · 2026Review
- Development and validation of embedded multilayer attention graph convolution neural network models for predicting gut microbe-disease associations.Frontiers in microbiology · 2026Article
- Article
- Bacterial communities co-develop with respiratory immunity early in life, linking dysbiosis to systemic monocyte signature and wheezing.Science advances · 2025Article
- Current and Emerging Therapies for Prevention and Treatment of Bronchopulmonary Dysplasia in Preterm Infants.Paediatric drugs · 2025Review
- Article
- Characteristics of the oropharyngeal microbiota among infants with pneumonia and their effects on immune response and subsequent respiratory morbidity.European journal of pediatrics · 2023Article
- Age-Related Changes in the Nasopharyngeal Microbiome Are Associated With Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Infection and Symptoms Among Children, Adolescents, and Young Adults.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2022Article
- Airway microbiome dynamics and relationship to ventilator-associated infection in intubated pediatric patients.Pediatric pulmonology · 2022Article
- Salbutamol Transport and Deposition in the Upper and Lower Airway with Different Devices in Cats: A Computational Fluid Dynamics Approach.Animals : an open access journal from MDPI · 2021Article
- Cardiorespiratory performance capacity and airway microbiome in patients following primary repair of esophageal atresia.Pediatric research · 2021Article
- Diversity and genomic determinants of the microbiomes associated with COVID-19 and non-COVID respiratory diseases.Gene reports · 2021Article
- Rapid Increase of Oral Bacteria in Nasopharyngeal Microbiota After Antibiotic Treatment in Children With Invasive Pneumococcal Disease.Frontiers in cellular and infection microbiology · 2021Article
- [A review on the characteristics of microbiome and their association with diseases in preterm infants].Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics · 2020Review
- Longitudinal Associations of the Cystic Fibrosis Airway Microbiome and Volatile Metabolites: A Case Study.Frontiers in cellular and infection microbiology · 2020Article
- Changes in microbiome diversity following beta-lactam antibiotic treatment are associated with therapeutic versus subtherapeutic antibiotic exposure in cystic fibrosis.Scientific reports · 2019Article
- Pulmonary Function Testing in Pediatric Pneumonia Patients With Wheezing Younger Than 3 Years of Age.Global pediatric health · 2019Article
- Bronchopulmonary dysplasia or chronic lung disease: an appeal to standardize nomenclature.Pediatric research · 2018Article
- Pediatric asthma comprises different phenotypic clusters with unique nasal microbiotas.Microbiome · 2018Article
- Antibiotic multidrug resistance in the cystic fibrosis airway microbiome is associated with decreased diversity.Heliyon · 2018Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 3 institutions in 2 countries.
Funding
Abstract
The study of the airway microbiome in children is an area of emerging research, especially in relation to the role microbial diversity may play in acute and chronic inflammation. Three such pediatric airway diseases include cystic fibrosis, asthma, and chronic lung disease of prematurity. In cystic fibrosis, the presence of Pseudomonas spp. is associated with decreased microbial diversity. Decreasing microbial diversity is also associated with poor lung function. In asthma, early viral infections appear to drive changes in bacterial diversity which may be associated with asthma risk. Premature infants with Ureaplasma spp. are at higher risk for chronic lung disease due to inflammation. Microbiome changes due to prematurity also appear to affect the inflammatory response to viral infections post-natally. Importantly, microbial diversity can be measured using metataxonomic (e.g., 16S rRNA sequencing) and metagenomic (e.g., shotgun sequencing) approaches. A metagenomics approach may be preferable as it can provide further granularity of the sample composition, identifying the bacterial species or strain, information on additional microbial components, including fungal and viral components, information about functional genomics of the microbiome, and information about antimicrobial resistance mutations. Future studies of pediatric airway diseases incorporating these techniques may provide evidence for new treatment approaches for these vulnerable patient populations.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.