Evidence map›Paper›PMID 29225130›Full record

ArticleBiochemical pharmacology2018

On the G protein-coupling selectivity of the native A

Zhan-Guo Gao, Asuka Inoue, Kenneth A Jacobson

Open access · greenAbstract read
In one paragraph

Article in Biochemical pharmacology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.

0numbers the graph read from it
0cells of the map it votes in
32citing papers in PubMed
3.2field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

32 citing papers in PubMed, 45 citations in OpenAlex.

  1. APurinergic signalling · 2025
    Article
  2. APurinergic signalling · 2025
    Review
  3. Review
  4. Article
  5. Article
  6. Review
  7. Review
  8. Species dependence of APurinergic signalling · 2023
    Review
  9. AiScience · 2023
    Article
  10. Review
  11. Crystal structure of adenosine ACommunications chemistry · 2023
    Article
  12. Article
  13. Article
  14. Agonist-Dependent Coupling of the Promiscuous Adenosine AACS pharmacology & translational science · 2022
    Article
  15. Review
  16. Article
  17. Review
  18. Review
  19. Structure and function of adenosine receptor heteromers.Cellular and molecular life sciences : CMLS · 2021
    Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 3 institutions in 2 countries.

Zhan-Guo GaoMolecular Recognition Section, Laboratory of Bioorganic Chemistry, NIDDK, National Institutes of Health, 9000 Rockville Pike, Bethesda, MD 20892, USA. Electronic address: zg21o@nih.gov.
Asuka InoueGraduate School of Pharmaceutical Sciences, Tohoku University, Sendai, Miyagi 980-8578, Japan.
Kenneth A JacobsonMolecular Recognition Section, Laboratory of Bioorganic Chemistry, NIDDK, National Institutes of Health, 9000 Rockville Pike, Bethesda, MD 20892, USA. Electronic address: kennethJ@niddk.nih.gov.
National Institute of Diabetes and Digestive and Kidney Diseases · USNational Institutes of Health · USTohoku University · JP

Funding

Development Of Drugs Acting At Adenosine ReceptorsZIADK031117 · NIDDK · NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES · PI JACOBSON, KENNETH ALAN · 2009 to 2025
$10.4M
Intramural NIH HHS Z99 DK999999Intramural NIH HHS ZIA DK031117
6 · The paper itself

Abstract

A

Indexed as

Signal TransductionAdenosine A2 Receptor AgonistsAnimalsCalciumCell Line, TumorCyclic AMPDrug DiscoveryGene ExpressionGTP-Binding ProteinsHEK293 CellsHumansMAP Kinase Signaling SystemProtein BindingReceptor, Adenosine A2BAdenosine A2 Receptor AgonistsCalciumCyclic AMPGTP-Binding ProteinsReceptor, Adenosine A2BA2B adenosine receptorAdenosine receptorCalciumERK1/2GPCRG protein

Identifiers

PMID29225130
PMCPMC5899946
OpenAlexW2774982216

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.