Evidence map›Paper›PMID 29224938›Full record

ArticleThe Journal of pediatrics2018

Subclinical Atherosclerosis in Pediatric Liver Transplant Recipients: Carotid and Aorta Intima-Media Thickness and Their Predictors.

Emily R Perito, Andrew Phelps, Tabitha Vase, Vickie A Feldstein, Robert H Lustig, Philip Rosenthal

Registry-linked trialAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of pediatrics, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07660679 (The Effect of Preoperative Carotid Intima-Media Thickness on Intraoperative Hemodynamic Profile in Liver Transplant Patients), which is not on this map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07660679 recruitingnot on this mapstarted 2026, after this paper: background citation

The Effect of Preoperative Carotid Intima-Media Thickness on Intraoperative Hemodynamic Profile in Liver Transplant Patients

TypeobservationalSponsorDicle UniversityRan2026 to 2026Enrolled54ConditionsLiver Transplantation, Carotid Intima-media Thickness
3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Emily R PeritoDepartment of Pediatrics, UCSF Benioff Children's Hospital, University of California, San Francisco, San Francisco, CA; Department of Epidemiology and Biostatistics, UCSF Benioff Children's Hospital, University of California, San Francisco, San Francisco, CA. Electronic address: emily.perito@ucsf.edu.
Andrew PhelpsDepartment of Radiology and Biomedical Imaging, UCSF Benioff Children's Hospital, University of California, San Francisco, San Francisco, CA.
Tabitha VaseSchool of Medicine, UCSF Benioff Children's Hospital, University of California, San Francisco, San Francisco, CA.
Vickie A FeldsteinDepartment of Radiology and Biomedical Imaging, UCSF Benioff Children's Hospital, University of California, San Francisco, San Francisco, CA.
Robert H LustigDepartment of Pediatrics, UCSF Benioff Children's Hospital, University of California, San Francisco, San Francisco, CA.
Philip RosenthalDepartment of Pediatrics, UCSF Benioff Children's Hospital, University of California, San Francisco, San Francisco, CA; Department of Surgery, UCSF Benioff Children's Hospital, University of California, San Francisco, San Francisco, CA.

Funding

Engaging University of California Stakeholders for Biorespository ResearchUL1TR000004 · NCATS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI GRANDIS, JENNIFER RUBIN · 2012 to 2015
$78.0M
UCSF Liver Core CenterP30DK026743 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI JACQUELYN J. MAHER · 1986 to 2026
$30.7M
Clinical and Transtional Science InstituteKL2TR000143 · NCATS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI GRANDIS, JENNIFER RUBIN · 2012 to 2015
$11.9M
Immunosuppression Withdrawal for Stable Pediatric Liver Transplant RecipientsU01AI100807 · NIAID · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI FENG, SANDY · 2012 to 2016
$9.5M
TRAINING PROGRAM IN PEDIATRIC GASTROENTEROLOGY/NUTRITIONT32DK007762 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI James Bayrer · 1998 to 2026
$7.3M
Metabolic Syndrome after Pediatric Liver Transplant: Causes and ConsequencesK23DK099253 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI PERITO, EMILY ROTHBAUM · 2014 to 2018
$938k
NCATS NIH HHS KL2 TR000143NCATS NIH HHS UL1 TR000004NIAID NIH HHS U01 AI100807NIDDK NIH HHS K23 DK099253NIDDK NIH HHS P30 DK026743NIDDK NIH HHS T32 DK007762
6 · The paper itself

Abstract

objectiveTo investigate prevalence and predictors of cardiovascular risk in pediatric liver transplant recipients using noninvasive markers of subclinical atherosclerosis: carotid intima-media thickness (cIMT) and aorta intima-media thickness (aIMT). STUDY

designCross-sectional study of 88 pediatric liver transplant recipients. The cIMT and aIMT were measured by ultrasound imaging using standardized protocol.

resultsParticipants were 15.4 ± 4.8 years of age, and 11.2 ± 5.6 years post-transplantation. The cIMT and aIMT were both higher in males than females. In analyses adjusted for sex, age, and height, the cIMT was higher in subjects transplanted for chronic/cirrhotic liver disease and lower in subjects on cyclosporine (n = 9) than tacrolimus (n = 71). The cIMT was not associated with rejection history or current corticosteroid use. The cIMT increased with increasing diastolic blood pressure and triglycerides. The aIMT (n = 83) also increased with age, and its rate of increase post-transplant varied by age at transplantation. In adjusted analyses, aIMT was higher in subjects with glucose intolerance. In analysis of patients ≤20 years of age for whom blood pressure percentiles could be calculated (n = 66), aIMT increased with increasing diastolic blood pressure percentile (0.010 mm per 5-percentile; 95% CI, 0.000-0.021; P = 0.05). Neither the cIMT nor the aIMT was associated with obesity, systolic hypertension, or other dyslipidemia at study visit.

conclusionMeasures of long-term cardiovascular risk were associated with conditions that are more common in pediatric liver transplant recipients than nontransplanted peers, namely, diastolic hypertension and glucose intolerance. Larger, longitudinal studies are warranted to investigate whether cIMT could be useful for stratifying these patients' cardiovascular risk-and potential need for proactive intervention-during long-term follow-up.

Indexed as

AdolescentAorta, AbdominalAtherosclerosisBiomarkersCarotid ArteriesCarotid Intima-Media ThicknessChildCross-Sectional StudiesFemaleHumansLiver TransplantationMaleMetabolic SyndromePrevalenceRisk AssessmentRisk FactorsBiomarkersatherosclerosiscardiovascular riskchildrenliver transplantationmetabolic syndrome

Identifiers

PMID29224938
PMCPMC5794603

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.