Evidence map›Paper›PMID 29224854›Full record

ReviewInfectious disease clinics of North America2018

Encephalitis in US Children.

Kevin Messacar, Marc Fischer, Samuel R Dominguez, Kenneth L Tyler, Mark J Abzug

Abstract readReview
In one paragraph

Review in Infectious disease clinics of North America, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers.

0numbers the graph read from it
0cells of the map it votes in
45citing papers in PubMed
2.9field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

45 citing papers in PubMed, 101 citations in OpenAlex.

  1. Article
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  3. Review
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  11. Changes in etiology, diagnostic challenges, and prognostic factors in pediatric acute encephalitis: Insights from an 18-year retrospective study.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2025
    Article
  12. Review
  13. Article
  14. Article
  15. Observational
  16. Article
  17. Review
  18. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 1 country.

Kevin MessacarDepartment of Pediatrics, University of Colorado, Children's Hospital Colorado, B055, 13123 East 16th Avenue, Aurora, CO 80045, USA. Electronic address: kevin.messacar@childrenscolorado.org.
Marc FischerSurveillance and Epidemiology Activity, Arboviral Diseases Branch, Centers for Disease Control and Prevention, 3156 Rampart Road, Fort Collins, CO 80521, USA.
Samuel R DominguezDepartment of Pediatrics, University of Colorado, Children's Hospital Colorado, B055, 13123 East 16th Avenue, Aurora, CO 80045, USA.
Kenneth L TylerDepartment of Neurology, University of Colorado, 12700 East 19th Avenue, B182, Aurora, CO 80045, USA.
Mark J AbzugDepartment of Pediatrics, University of Colorado, Children's Hospital Colorado, B055, 13123 East 16th Avenue, Aurora, CO 80045, USA.
Children's Hospital Colorado · USUniversity of Colorado Denver · USCenters for Disease Control and Prevention · US

Funding

EV-D68-induced CNS disease: pathogenic mechanisms and identification of therapeutic targets.R01NS101208 · NINDS · UNIVERSITY OF COLORADO DENVER · PI TYLER, KENNETH L. · 2018 to 2021
$1.5M
Identification and evaluation of novel therapeutic targets for virus-induced neuronal diseaseR33AI101064 · NIAID · UNIVERSITY OF COLORADO DENVER · PI TYLER, KENNETH L. · 2014 to 2016
$1.4M
Implementation and Effectiveness of a Rapid Cerebrospinal Fluid Diagnostics Program for Children with Suspected Central Nervous System InfectionK23AI128069 · NIAID · UNIVERSITY OF COLORADO DENVER · PI MESSACAR, KEVIN BRETT · 2017 to 2021
$878k
Identification and evaluation of novel therapeutic strategies for Zika virus-induced CNS diseaseR21NS103186 · NINDS · UNIVERSITY OF COLORADO DENVER · PI TYLER, KENNETH L. · 2017 to 2018
$428k
EV-D68-induced CNS disease: pathogenic mechanisms and identification of therapeutic targets.R56NS101208 · NINDS · UNIVERSITY OF COLORADO DENVER · PI TYLER, KENNETH L. · 2017 to 2017
$340k
Role of Microglia in Protection Against West Nile Virus-induced CNS Injury: mechanisms and treatment strategiesI01BX000963 · VA · VA EASTERN COLORADO HEALTH CARE SYSTEM · PI Kenneth L. Tyler · 2012 to 2026
–
BLRD VA I01 BX000963NIAID NIH HHS K23 AI128069NIAID NIH HHS R33 AI101064NINDS NIH HHS R01 NS101208NINDS NIH HHS R21 NS103186NINDS NIH HHS R56 NS101208
6 · The paper itself

Abstract

Encephalitis is an uncommon but severe disease characterized by neurologic dysfunction with central nervous system inflammation. Children with encephalitis should receive supportive care and empiric therapies for common and treatable causes while prioritizing diagnostic evaluation for common, treatable, and high-risk conditions. Even with an extensive diagnostic workup, an infectious cause is identified in less than half of cases, suggesting a role for postinfectious or noninfectious processes.

Indexed as

ArbovirusesBrainChildDiagnosis, DifferentialEncephalitisEnterovirusFemaleHerpes SimplexHumansMaleMeningoencephalitisMyelitisUnited StatesAnti-NMDAArbovirusEncephalitisEnterovirusHerpes simplex virusMeningoencephalitisMyelitis

Identifiers

PMID29224854
PMCPMC5801071
OpenAlexW2775258249

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.