ArticleNeuron2017
Injecting Instructions into Premotor Cortex.
Article in Neuron, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed.
- Integration of learned artificial sensation with vision during freely moving navigation.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Microstructure and gene expression influence gyrification in amyotrophic lateral sclerosis.Brain communications · 2026Article
- Intracortical Microstimulation in Brain-Computer Interfaces: Evoking Perception and Plasticity.Cyborg and bionic systems (Washington, D.C.) · 2026Review
- Disentangling indirect versus direct effects of somatosensory cortex microstimulation on neurons in primary motor and ventral premotor cortex.Journal of neural engineering · 2025Article
- Training-Free Regulation of Grasping by Intracortical Tactile Feedback Designed via S1-M1 Communication.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Injecting information in the cortical reach-to-grasp network is effective in ventral but not dorsal nodes.Cell reports · 2025Article
- Continuous sensorimotor transformation enhances robustness of neural dynamics to perturbation in macaque motor cortex.Nature communications · 2025Article
- Smoking and High-Altitude Exposure Affect Intrinsic Neural Activity: A fMRI Study of Interactive Effects.Addiction biology · 2025Article
- Article
- Association of Cortical Gyrification With Imaging and Serum Biomarkers in Patients With Parkinson Disease.Neurology · 2023Article
- Cortical and subcortical morphological alterations in motor subtypes of Parkinson's disease.NPJ Parkinson's disease · 2022Article
- Spatial neglect treatment: The brain's spatial-motor Aiming systems.Neuropsychological rehabilitation · 2022Review
- Motor training-related brain reorganization in patients with cerebellar degeneration.Human brain mapping · 2022Article
- Injecting Information into the Mammalian Cortex: Progress, Challenges, and Promise.The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry · 2021Review
- Article
- Abnormal resting-state functional connectivity of hippocampal subfields in patients with major depressive disorder.BMC psychiatry · 2020Article
- The critical stability task: quantifying sensory-motor control during ongoing movement in nonhuman primates.Journal of neurophysiology · 2018Article
- Highlights from the 28th Annual Meeting of the Society for the Neural Control of Movement.Journal of neurophysiology · 2018Article
- Commentary: Injecting Instructions into Premotor Cortex.Frontiers in cellular neuroscience · 2018Article
- Motor systems: Cortical instructions.Nature reviews. Neuroscience · 2017Article
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2 authors.
Funding
Abstract
The premotor cortex (PM) receives inputs from parietal cortical areas representing processed visuospatial information, translates that information into programs for particular movements, and communicates those programs to the primary motor cortex (M1) for execution. Consistent with this general function, intracortical microstimulation (ICMS) in the PM of sufficient frequency, amplitude, and duration has been shown to evoke complex movements of the arm and hand that vary systematically depending on the locus of stimulation. Using frequencies and amplitudes too low to evoke muscle activity, however, we found that ICMS in the PM can provide instructions to perform specific reach, grasp, and manipulate movements. These instructed actions were not fixed but rather were learned through associations between the arbitrary stimulation locations and particular movements. Low-amplitude ICMS at different PM locations thus evokes distinguishable experiences that can become associated with specific movements arbitrarily, providing a novel means of injecting information into the nervous system.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.