SynthesisTherapeutic advances in cardiovascular disease2018
Algorithms used to identify ventricular arrhythmias and sudden cardiac death in retrospective studies: a systematic literature review.
Synthesis in Therapeutic advances in cardiovascular disease, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.
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Who cites it
9 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Diagnostic Algorithms for Cardiovascular Death in Administrative Claims Databases: A Systematic Review.Drug safety · 2019Pooled it
- Enhancing Evidence Generation by Linking Randomized Clinical Trials to Real-World Data: The INVESTED-Medicare Linkage Study.Clinical pharmacology and therapeutics · 2026Article
- Hospitalization for Malignant Arrhythmias Following Initiation of Donepezil: A Retrospective Cohort Study.Pharmacoepidemiology and drug safety · 2026Article
- Dexmedetomidine on supraventricular tachycardia in critical illness: a time-dependent propensity score matching study.Critical care (London, England) · 2026Article
- Factors associated with clinically diagnosed long QT syndrome in Korean adults: a nationwide case-control study.Frontiers in pharmacology · 2026Article
- Trends in sudden cardiac death mortality in Italy, 2013-2019.Internal and emergency medicine · 2024Article
- Cardiovascular Safety of Metoclopramide Compared to Domperidone: A Population-Based Cohort Study.Journal of the Canadian Association of Gastroenterology · 2021Article
- Predictors of Sudden Cardiac Arrest Among Patients With Post-Myocardial Infarction Ejection Fraction Greater Than 35.Journal of the American Heart Association · 2021Article
- Disparities in Care and Mortality Among Homeless Adults Hospitalized for Cardiovascular Conditions.JAMA internal medicine · 2020Article
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Drug-induced QT interval prolongation may increase the risk of sudden cardiac death or ventricular arrhythmias (SCD/VA), and therefore affects the safety profile of medications. Administrative databases can be used to inform pharmacoepidemiologic drug safety studies for such rare events. In order to compare event rates between studies, validated operational definitions of these events are needed. We conducted a systematic literature review in PubMed to identify algorithms for SCD/VA. Twenty-two studies were included in the review. Fifteen (68%) studies evaluated International Classification of Diseases, 9th revision (ICD-9) based medical data, of which six utilized a common, validated operational definition. This algorithm was based on principal hospitalization discharge diagnosis or first-listed emergency department visit diagnosis, with an average positive predictive value (PPV) of 85%. Four studies evaluated ICD-9 based death data, of which three utilized a common algorithm with an average PPV of 88%. Further validation of ICD, 10th revision algorithms are needed. In conclusion, we identified a validated algorithm for SCD/VA in medical data, as well as in death data. As such, to ensure comparability between new research and the existing literature, pharmacoepidemiologic research in this area should utilize common, validated algorithms, such as the ones identified in our review, to operationally define these events.
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