Evidence map›Paper›PMID 29224110›Full record

ReviewAdvances in experimental medicine and biology2017

Sex Differences in Androgen Regulation of Metabolism in Nonhuman Primates.

Cadence True, David H Abbott, Charles T Roberts, Oleg Varlamov

Open access · greenAbstract readReview
In one paragraph

Review in Advances in experimental medicine and biology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
8.0field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 10 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 3 institutions in 1 country.

Cadence TrueDivision of Cardiometabolic Health, Oregon National Primate Research Center, Oregon Health & Science University, Portland, OR, USA.
David H AbbottDepartment of Obstetrics and Gynecology and the Wisconsin National Primate Research Center, University of Wisconsin, Madison, WI, USA.
Charles T RobertsDivision of Cardiometabolic Health, Oregon National Primate Research Center, Oregon Health & Science University, Portland, OR, USA. robertsc@ohsu.edu.
Oleg VarlamovDivision of Cardiometabolic Health, Oregon National Primate Research Center, Oregon Health & Science University, Portland, OR, USA.
Oregon National Primate Research Center · USOregon Health & Science University · USUniversity of Wisconsin–Madison · US

Funding

Upgrade of confocal microscopy at the Oregon National Primate Research CenterP51OD011092 · OD · OREGON HEALTH & SCIENCE UNIVERSITY · PI Bonnie J. Nagel · 2012 to 2026
$203.9M
WNPRC Supplemental Request for Nonhuman Primate Enclosures to Equip HIV/AIDS-Related Research FacilitiesP51OD011106 · OD · UNIVERSITY OF WISCONSIN-MADISON · PI Dorota A. Grejner-Brzezinska · 2012 to 2026
$150.7M
Role of Androgen Excess in Provoking Oxidative Stress in FemalesP50HD044405 · NICHD · NORTHWESTERN UNIVERSITY AT CHICAGO · PI DUNAIF, ANDREA E · 2002 to 2017
$17.2M
PROJECT 4: ANDROGEN EXCESS IN ADIPOGENIC DYSFUNCTION IN PCOS WOMENP50HD071836 · NICHD · OREGON HEALTH & SCIENCE UNIVERSITY · PI STOUFFER, RICHARD L · 2014 to 2021
$14.7M
ANDROGENIZED FEMALE AS A MODEL FOR P0LYCYSTIC OVARIAN SYR01RR013635 · NCRR · UNIVERSITY OF WISCONSIN MADISON · PI ABBOTT, DAVID H · 1999 to 2002
$968k
Attenuation of androgen deprivation therapy-induced metabolic syndrome by dietR21AG047543 · NIA · OREGON HEALTH & SCIENCE UNIVERSITY · PI VARLAMOV, OLEG · 2013 to 2014
$481k
NIA NIH HHS R21 AG047543NICHD NIH HHS P50 HD044405NICHD NIH HHS P50 HD071836NIH HHS P51 OD011092NIH HHS P51 OD011106NIH HHS R01 RR013635
6 · The paper itself

Abstract

The in-depth characterization of sex differences relevant to human physiology requires the judicious use of a variety of animal models and human clinical data. Nonhuman primates (NHPs) represent an important experimental system that bridges rodent studies and clinical investigations. NHP studies have been especially useful in understanding the role of sex hormones in development and metabolism and also allow the elucidation of the effects of pertinent dietary influences on physiology pertinent to disease states such as obesity and diabetes. This chapter summarizes the current state of our understanding of androgen effects on male and female NHP metabolism relevant to hypogonadism in human males and polycystic ovary syndrome in human females. This review will also focus on the interaction between altered androgen levels and dietary restriction and excess, in particular the Western-style diet that underlies significant human pathophysiology.

Indexed as

Energy MetabolismAnimalsCaloric RestrictionDiet, WesternDisease Models, AnimalFemaleGonadal Steroid HormonesHumansHypogonadismMalePolycystic Ovary SyndromePrimatesRisk FactorsSex CharacteristicsSex FactorsSpecies SpecificityGonadal Steroid Hormones

Identifiers

PMID29224110
PMCPMC5893331
OpenAlexW2772678050

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.