ArticleOral and maxillofacial surgery2018
Differences between osteoradionecrosis and medication-related osteonecrosis of the jaw.
Article in Oral and maxillofacial surgery, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 40 citations in OpenAlex.
- [Expert consensus on perioperative management of tooth extraction in patients receiving denosumab therapy].Hua xi kou qiang yi xue za zhi = Huaxi kouqiang yixue zazhi = West China journal of stomatology · 2026Article
- Advanced Platelet-Rich Fibrin in Surgical Management of Medication-Related Osteonecrosis of the Jaw: A Prospective Case Series Study.Clinical and experimental dental research · 2026Article
- Involvement of resistant bacteria in the severity of refractory osteonecrosis of the jaw.Clinical oral investigations · 2025Article
- Successful surgical management of a patient with osteoradionecrosis of the jaw with RET fusion-positive advanced thyroid cancer: A case report.Experimental and therapeutic medicine · 2025Article
- The usefulness of different imaging modalities in mandibular osteonecrosis and osteomyelitis diagnosis.Scientific reports · 2025Article
- Role of Photodynamic Therapy in Osteonecrosis and Osteoradionecrosis of the Jaws: A Systematic Review.Journal of maxillofacial and oral surgery · 2024Review
- Pre- and Post-Operative Quality of Life in Patients with Osteoradionecrosis of the Jaw.Cancers · 2024Article
- Article
- Fractal analysis and assessment of lacunarity in mandibular osteoradionecrosis: a cross-sectional study with control group.Brazilian oral research · 2024Article
- Resemblances and differences between osteoradionecrosis of the jaw and medication-related osteonecrosis of the jaw.Medicine and pharmacy reports · 2024Article
- Secondary lesions of the mucous membrane of the oral cavity as a side effect of complex anticancer treatment: a literature review.Journal of medicine and life · 2023Review
- Organic Bone Matrix Component Type I and V Collagen Are Not Destructed in Bisphosphonate-Associated Osteonecrosis of the Jaws.Medicina (Kaunas, Lithuania) · 2022Article
- Article
- Fluorescence-guided surgery for osteoradionecrosis of the jaw: a retrospective study.The Journal of international medical research · 2022Article
- Targeted histological evaluation shows high incidence of actinomyces infection in medication-related osteonecrosis of the jaws.Scientific reports · 2022Article
- Periosteal reaction of medication-related osteonecrosis of the jaw (MRONJ): clinical significance and changes during conservative therapy.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2021Article
- Do various imaging modalities provide potential early detection and diagnosis of medication-related osteonecrosis of the jaw? A review.Dento maxillo facial radiology · 2021Review
- Oral management strategies for radiotherapy of head and neck cancer.The Japanese dental science review · 2020Review
- Clinical significance of periosteal reaction as a predictive factor for treatment outcome of medication-related osteonecrosis of the jaw.Journal of bone and mineral metabolism · 2019Article
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeThe appearance of osteoradionecrosis (ORN) and medication-related osteonecrosis of the jaw (MRONJ) is similar, but clinically important differences between ORN and MRONJ exist. The aim of this study was to compare the clinical data between ORN and MRONJ and to reveal the critical differences between these diseases.
methodsWe retrospectively reviewed the epidemiological data, clinical findings, and treatment in 27 ORN and 61 MRONJ patients. Radiographic signs before the initiation of treatment were also assessed.
resultsThe median age (P = 0.0474) and the ratio of female to male patients (P < 0.0001) were significantly higher in MRONJ patients. There were significantly more MRONJ patients who reported a history of pain when compared with ORN patients (P = 0.0263). As an aetiological factor, tooth extraction was significantly more relevant to MRONJ than ORN (P = 0.0352). When assessing the radiographic signs on computed tomographic images, periosteal reaction was found only in MRONJ patients (P = 0.0158). Minimal debridement was performed significantly more frequently for MRONJ (P = 0.0093), and by contrast, surgical resection was performed more frequently for ORN (P = 0.0002).
conclusionsUnderstanding the clinical and underlying pathological differences between ORN and MRONJ probably contributes to the selection of appropriate treatment for each patient.
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